Pipemidic acid is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase; it exhibits antibacterial activity. Pipemidic acid also inhibits ATP-sensitive K+ channels, inducing insulin release in vitro, suggesting potential a potential link to hypoglycemia. High doses of pipemidic acid induce cartilage toxicity (arthropathy) in neonatal mice.
| Cas No. | 51940-44-4 |
|---|---|
| Purity | ≥98% |
| Formula | C14H17N5O3 |
| Formula Wt. | 303.32 |
| IUPAC Name | 8-ethyl-5-oxo-2-piperazin-1-ylpyrido[2,3-d]pyrimidine-6-carboxylic acid |
| Appearance | White to off white powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| MSDS | P3461 MSDS PDF |
|---|---|
| Info Sheet | P3461 Info Sheet PDF |
Aubry A, Pan XS, Fisher LM, et al. Mycobacterium tuberculosis DNA gyrase: interaction with quinolones and correlation with antimycobacterial drug activity. Antimicrob Agents Chemother. 2004 Apr;48(4):1281-8. PMID: 15047530.
Maeda N, Tamagawa T, Niki I, et al. Increase in insulin release from rat pancreatic islets by quinolone antibiotics. Br J Pharmacol. 1996 Jan;117(2):372-6. PMID: 8789393.
Linseman DA, Hampton LA, Branstetter DG. Quinolone-induced arthropathy in the neonatal mouse. Morphological analysis of articular lesions produced by pipemidic acid and ciprofloxacin. Fundam Appl Toxicol. 1995 Nov;28(1):59-64. PMID: 8566484.
Aoyama H, Sato K, Fujii T, et al. Purification of Citrobacter freundii DNA gyrase and inhibition by quinolones. Antimicrob Agents Chemother. 1988 Jan;32(1):104-9. PMID: 2831810.
