LKT/POLYMYXIN B SULFATE/P5747/250 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/POLYMYXIN B SULFATE/P5747/250 mg

LKT/POLYMYXIN B SULFATE/P5747/250 mg

商品编号： P5747-250mg

品牌： lktlabs

市场价： ¥1040.00

美元价： 624.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDP5747

CasNo.1405-20-5

Purity≥6500iu/mg

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

PolymyxinBisamixtureofpolymyxinB1,B2,B3andB1-1sulfates;polymyxinBisacationiclipidoligopeptidederivedfromBacilluspolymyxathatdisplaysantibacterialactivityagainstallgram-negativebacteriaexceptspeciesofProteus.PolymyxinBkillsbothproliferativeandquiescentcellsinvitro.PolymyxinBinhibitscellularrespirationbyinhibitingtypeIINADH-quinoneoxidoreductaseactivity.Thiscompoundalsoinducesaggregationoflipopolysaccharide(LPS)inbacterialcellmembranes,alteringmembranepotentialandcausingleakageofcellularcomponents.PolymyxinBhasbeenusedtotreatsepticshockinducedbyLPSofgram-negativebacteria,preventingLPS-inducedcaspaseactivity,Fasexpression,Bax/Bcl-2ratioalteration,andapoptosis.

ProductInfo

ShippingandStorage

CasNo.	1405-20-5
Purity	≥6500iu/mg
Formula	C₅₆H₁₀₀N₁₆O₁₇S
IUPACName	N-[4-amino-1-[[1-[[4-amino-1-oxo-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide;sulfuricacid
Synonym
Appearance	Whitetooffwhitepowder

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

InfoSheet	P5747InfoSheetPDF

References

DerisZZ,AkterJ,SivanesanS,etal.AsecondarymodeofactionofpolymyxinsagainstGram-negativebacteriainvolvestheinhibitionofNADH-quinoneoxidoreductaseactivity.JAntibiot(Tokyo).2013Oct30.[Epubaheadofprint].PMID:24169795.

ZhaiB,LinX.EvaluationoftheanticryptococcalactivityoftheantibioticpolymyxinBinvitroandinvivo.IntJAntimicrobAgents.2013Mar;41(3):250-4.PMID:23313397

DominguesMM,InácioRG,RaimundoJM,etal.BiophysicalcharacterizationofpolymyxinBinteractionwithLPSaggregatesandmembranemodelsystems.Biopolymers.2012;98(4):338-44.PMID:23193598.

MartinEL,RanieriVM.EndotoxinremovalbypolymyxinBimmobilizedcartridgeinactivatescirculatingproapoptoticfactors.ContribNephrol.2010;167:65-76.PMID:20519900.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂