Povidone (polyvinyl pyrrolidone polymer) is an antibacterial compound used as a disinfectant in surgical settings. When combined with iodine, povidone exhibits anticancer activity, inhibiting proliferation and inducing necrotic cell death in mesothelioma cells. Povidone may induce depurination and cleavage of DNA. This compound is also occasionally used as a stabilizer in drug formulations.
| Cas No. | 25655-41-8 |
|---|---|
| Purity | ≥98% |
| Formula | C6H9I2NO |
| Formula Wt. | 364.94 |
| Chemical Name | 1-Ethenyl-2-pyrrolidinone homopolymer compound with iodine |
| IUPAC Name | 1-ethenylpyrrolidin-2-one;molecular iodine |
| Synonym | Betadine; Isodine; Ultradine |
| Melting Point | ~300°C |
| Solubility | Soluble in water and alcohol. Insoluble in most oragnic solvents |
| Appearance | Yellowish brown to reddish brown powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| MSDS | P5885 MSDS PDF |
|---|---|
| Info Sheet | P5885 Info Sheet PDF |
Fiorelli A, Pentimalli F, D'Urso V, et al. Antineoplastic activity of povidone-iodine on different mesothelioma cell lines: results of in vitro study. Eur J Cardiothorac Surg. 2014 Jun;45(6):993-1000. PMID: 24394552.
Song M, Zeng L, Hong X, et al. Polyvinyl pyrrolidone promotes DNA cleavage by a ROS-independent and depurination mechanism. Environ Sci Technol. 2013 Mar 19;47(6):2886-91. PMID: 23425130.
Haznar-Garbacz D, Garbacz G, Eisenächer F, et al. A novel liquefied gas based oral controlled release drug delivery system for liquid drug formulations. Eur J Pharm Biopharm. 2012 Jun;81(2):334-8. PMID: 22426133.
Major T Sr, Major M, Bognár C, et al. Clinico-bacteriological examination of Betadine skin disinfectant fluid and liquid soap in hospitalized patients and hospital employees. Ther Hung. 1993;41(3):114-8. PMID: 8202868.
