PrulifloxacinisafluoroquinoloneantibioticwithbroadspectrumantibacterialactivityagainstEscherichia,Proteus,Staphylococcus,Streptococcus,andHaemophilus.Likeotherfluoroquinolones,prulifloxacininhibitsDNAgyraseandtopoisomeraseIV,preventingDNAsynthesis,repair,andtranscription.Clinically,prulifloxacinisusedtotreatinfectionsoftherespiratorysystemandurinarytract.
| CasNo. | 123447-62-1 |
|---|---|
| Purity | ≥97% |
| Formula | C21H20FN3O6S |
| FormulaWt. | 461.46 |
| ChemicalName | 1H,4H-(1,3)Thiazeto(3,2-a)quinoline-3-carboxylicacid,6-fluoro-1-methyl-7-(4-((5-methyl-2-oxo-1,3-dioxol-4-yl)methyl)-1-piperazinyl)-4-oxo- |
| IUPACName | 6-fluoro-1-methyl-7-[4-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl]piperazin-1-yl]-4-oxo-1H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylicacid |
| Synonym | (+-)-7-(4-((Z)-2,3-Dihydroxy-2-butenyl)-1-piperazinyl)-6-fluoro-1-methyl-4-oxo-1H,4H-(1,3)thiazeto(3,2-a)quinoline-3-carboxylicacid,cycliccarbonate |
| Solubility | solublein0.1mol/LNaOH,slightlysolubleinacetonitrileandglacialaceticacid£¨practicallyinsolubleinwater,methanolethanoland0.1mol£ØLHCL£ª |
| Appearance | YellowishCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | P7082InfoSheetPDF |
|---|
KarageorgopoulosDE,MarakiS,VatopoulosAC,etal.Antimicrobialactivityofprulifloxacinincomparisonwithotherfluoroquinolonesagainstcommunity-acquiredurinaryandrespiratorypathogensisolatedinGreece.EurJClinMicrobiolInfectDis.2013Nov;32(11):1417-22.PMID:23686506.
CastoraFJ,VisseringFF,SimpsonMV.TheeffectofbacterialDNAgyraseinhibitorsonDNAsynthesisinmammalianmitochondria.BiochimBiophysActa.1983Sep9;740(4):417-27.PMID:6309236.
