LKT/PSORALIDIN/P7359/10 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/PSORALIDIN/P7359/10 mg

LKT/PSORALIDIN/P7359/10 mg

商品编号： P7359-10mg

品牌： lktlabs

市场价： ¥2580.00

美元价： 1548.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDP7359

CasNo.18642-23-4

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

PsoralidinisaphenoloriginallyfoundinPsoraleacoryfoliathatexhibitsantibacterial,antioxidative,anticancer,andantidepressantactivities.Psoralidinisabroadspectrumantibiotic,inhibitingbothgrampositiveandgramnegativebacteria.Invariouscellularmodels,psoralidininhibitsphosphorylationofIκBkinase,inhibitstranslocationofNF-κB,downregulatesexpressionofiNOS,andinducesexpressionofquinonereductase.PsoralidinalsoinhibitsactivationofEGRF,downregulatingMAPKsignalingandinhibitingproliferationofandrogen-independentprostatecancercells.Inbreastcancerstemcells,thiscompounddownregulatesNotch1signalingandinducesapoptosis,inhibitingcellgrowth.Additionally,psoralidinmodulateslevelsofSEROtonin(5-HT)anddopamineanddecreasesstress-inducedexpressionofcorticotropin-releasingfactor(CRF)andadrenocorticotropichormone(corticotropin;ACTH).Intheforcedswimtest,ananimalmodelofdepression-likeactivity,psoralidindecreasedimmobilitytimeandincreasedswimmingbehaviorwithoutaffectinggenerallocomotoractivity.

ProductInfo

CasNo.	18642-23-4
Purity	≥98%
Formula	C₂₀H₁₆O₅
FormulaWt.	336.34
ChemicalName	3,9-Dihydroxy-2-(3-methyl-2-butenyl)-6H-benzofuro[3,2-c][1]benzopyran-6-one
IUPACName	3,9-dihydroxy-2-(3-methylbut-2-enyl)-[1]benzofuro[3,2-c]chromen-6-one
Synonym	6-(3-methylbut-2-enyl)coumestrol
MeltingPoint	290-292°C
Appearance	Lightyellowpowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

InfoSheet	P7359InfoSheetPDF

References

SumanS,DasTP,DamodaranC.SilencingNOTCHsignalingcausesgrowtharrestinbothbreastcancerstemcellsandbreastcancercells.BrJCancer.2013Nov12;109(10):2587-96.PMID:24129237.

ChopraB,DhingraAK,DharKL.PsoraleacorylifoliaL.(Buguchi)-folkloretomodernevidence:review.Fitoterapia.2013Oct;90:44-56.PMID:23831482.

ChiouWF,DonMJ,LiaoJF,etal.PsoralidininhibitsLPS-inducediNOSexpressionviarepressingSyk-mediatedactivationofPI3K-IKK-IκBsignalingpathways.EurJPharmacol.2011Jan10;650(1):102-9.PMID:20951127.

KumarR,SrinivasanS,PahariP,etal.Activatingstress-activatedproteinkinase-mediatedcelldeathandinhibitingepidermalgrowthfactorreceptorsignaling:apromisingtherapeuticstrategyforprostatecancer.MolCancerTher.2010Sep;9(9):2488-96.PMID:20736346.

LeeSJ,NamKW,MarW.InductionofquinonereductaseactivitybypsoralidinisolatedfromPsoraleacorylifoliainmousehepa1c1c7cells.ArchPharmRes.2009Jul;32(7):1061-5.PMID:19641888.

YiLT,LiYC,PanY,etal.Antidepressant-likeeffectsofpsoralidinisolatedfromtheseedsofPsoraleaCorylifoliaintheforcedswimmingtestinmice.ProgNeuropsychopharmacolBiolPsychiatry.2008Feb15;32(2):510-9.PMID:18006202.

KhatuneNA,IslamME,HaqueME,etal.AntibacterialcompoundsfromtheseedsofPsoraleacorylifolia.Fitoterapia.2004Mar;75(2):228-30.PMID:15030932.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂