Description
Psoralidin is a phenol originally found in Psoralea coryfolia that exhibits antibacterial, antioxidative, anticancer, and antidepressant activities. Psoralidin is a broad spectrum antibiotic, inhibiting both gram positive and gram negative bacteria. In various cellular models, psoralidin inhibits phosphorylation of IκB kinase, inhibits translocation of NF-κB, downregulates expression of iNOS, and induces expression of quinone reductase. Psoralidin also inhibits activation of EGRF, downregulating MAPK signaling and inhibiting proliferation of androgen-independent prostate cancer cells. In breast cancer stem cells, this compound downregulates Notch1 signaling and induces apoptosis, inhibiting cell growth. Additionally, psoralidin modulates levels of serotonin (5-HT) and dopamine and decreases stress-induced expression of corticotropin-releasing factor (CRF) and adrenocorticotropic hormone (corticotropin; ACTH). In the forced swim test, an animal model of depression-like activity, psoralidin decreased immobility time and increased swimming behavior without affecting general locomotor activity.
References
Suman S, Das TP, Damodaran C. Silencing NOTCH signaling causes growth arrest in both breast cancer stem cells and breast cancer cells. Br J Cancer. 2013 Nov 12;109(10):2587-96. PMID: 24129237.
Chopra B, Dhingra AK, Dhar KL. Psoralea corylifolia L. (Buguchi) - folklore to modern evidence: review. Fitoterapia. 2013 Oct;90:44-56. PMID: 23831482.
Chiou WF, Don MJ, Liao JF, et al. Psoralidin inhibits LPS-induced iNOS expression via repressing Syk-mediated activation of PI3K-IKK-IκB signaling pathways. Eur J Pharmacol. 2011 Jan 10;650(1):102-9. PMID: 20951127.
Kumar R, Srinivasan S, Pahari P, et al. Activating stress-activated protein kinase-mediated cell death and inhibiting epidermal growth factor receptor signaling: a promising therapeutic strategy for prostate cancer. Mol Cancer Ther. 2010 Sep;9(9):2488-96. PMID: 20736346.
Lee SJ, Nam KW, Mar W. Induction of quinone reductase activity by psoralidin isolated from Psoralea corylifolia in mouse hepa 1c1c7 cells. Arch Pharm Res. 2009 Jul;32(7):1061-5. PMID: 19641888.
Yi LT, Li YC, Pan Y, et al. Antidepressant-like effects of psoralidin isolated from the seeds of Psoralea Corylifolia in the forced swimming test in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;32(2):510-9. PMID: 18006202.
Khatune NA, Islam ME, Haque ME, et al. Antibacterial compounds from the seeds of Psoralea corylifolia. Fitoterapia. 2004 Mar;75(2):228-30. PMID: 15030932.
