LKT/盐酸嘌呤霉素/P8168/100 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/盐酸嘌呤霉素/P8168/100 mg

LKT/盐酸嘌呤霉素/P8168/100 mg

商品编号： P8168-100mg

品牌： lktlabs

市场价： ¥6160.00

美元价： 3696.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDP8168

CasNo.58-58-2

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

PuromycinisanaminonucleosideantibioticcompoundoriginallyproducedbyStreptomycesalboniger.Puromycindisplaysantibacterialactivitythroughinhibitionofribosomalproteintranslation;itresemblesthe3’endoftRNAandisincorporatedintogrowingproteinchainsthroughtheribosomalAsite,inducingprematurechaintermination.PuromycinalsoinducesDNAdamagemediatedbyROSandoxidativestressinanimalmodels.Invitro,puromycininhibitsinsulin-stimulatedglycolysisbyinhibitinginsulinactivationofphosphofructokinase2.PuromycinalsoinhibitsdipeptidylpeptidaseII(DPP2;serinepeptidase)andmetallopeptidase.Additionally,thiscompoundinducesERKactivation-dependentapoptosisandmTOR-dependentautophagyinpodocytes,leADIngtoproteinuriaandglomerulardamage.

ProductInfo

CasNo.	58-58-2
Purity	≥98%
Formula	C₂₂H₂₉N₇O₅•2HCl
FormulaWt.	544.43
ChemicalName	(3"-[[(2S)-2-Amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3"-deoxy-N,N-dimethyl-adenosine
IUPACName	(2S)-2-amino-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide
Synonym	Achromycin(before1953);Stillomycin
MeltingPoint	175.5-177°C
Solubility	Solubleinwater.
Appearance	WhitePowder

ShippingandStorage

StoreTemp	4°C
ShipTemp	Ambient

Downloads

MSDS	P8168MSDSPDF
InfoSheet	P8168InfoSheetPDF

References

KangYL,SaleemMA,ChanKW,etal.Thecytoprotectiveroleofautophagyinpuromycinaminonucleosidetreatedhumanpodocytes.BiochemBiophysResCommun.2014Jan10;443(2):628-34.PMID:24333414.

LiuS,DingJ,FanQ,etal.Theactivationofextracellularsignal-regulatedkinaseisresponsIBLeforpodocyteinjury.MolBiolRep.2010Jun;37(5):2477-84.PMID:19728154.

MarshallCB,PippinJW,KrofftRD,etal.Puromycinaminonucleosideinducesoxidant-dependentDNAdamageinpodocytesinvitroandinvivo.KidneyInt.2006Dec;70(11):1962-73.PMID:17035936.

ProbstI,QuentmeierA,SchweickhardtC,etal.StimulationbyinsulinofglycolysisinculturedhepatocytesisattenuatedbyextracellularATPandpuromycinthroughpurine-dependentinhibitionofphosphofructokinase2activation.EurJBiochem.1989Jun15;182(2):387-93.PMID:2525468.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂