Pyrazinamide is a nicotinamide analog prodrug that exhibits antibiotic activity, inhibiting bacterial fatty acid synthetase I. Pyrazinamide displays antibacterial efficacy against both active and dormant bacteria, disrupting cell membranes, acidifying cytoplasm, and inhibiting membrane transport.
| Cas No. | 98-96-4 |
|---|---|
| Purity | ≥98% |
| Formula | C5H5N3O |
| Formula Wt. | 123.11 |
| IUPAC Name | pyrazine-2-carboxamide |
| Synonym | Pyrazinecarboxamide; Pyranzinoic acid amide |
| Melting Point | 189-191°C |
| Solubility | Soluble in water (15mg/mL). |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | P9671 Info Sheet PDF |
|---|
Singh P, Mishra AK, Malonia SK, et al. The paradox of pyrazinamide: an update on the molecular mechanisms of pyrazinamide resistance in Mycobacteria. J Commun Dis. 2006 Mar;38(3):288-98. PMID: 17373362.
Zhang Y, Wade MM, Scorpio A, et al. Mode of action of pyrazinamide: disruption of Mycobacterium tuberculosis membrane transport and energetics by pyrazinoic acid. J Antimicrob Chemother. 2003 Nov;52(5):790-5. PMID: 14563891.
