Nocodazole is an inhibitor of microtubule polymerization that exhibits anticancer and anti-parasitic activities. Nocodazole induces depolarization of the mitochondrial membrane, caspase activation, PARP cleavage, and apoptosis in chronic lymphocytic leukemia (CLL) cells. Nocodazole also kills Alveococcus larvocysts in vivo.
| Cas No. | 31430-18-9 |
|---|---|
| Purity | ≥98% |
| Formula | C14H11N3O3S |
| Formula Wt. | 301.32 |
| Chemical Name | [5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]- carbamic acid methyl ester |
| IUPAC Name | methyl N-[6-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate |
| Synonym | Oncodazole; R 17934 |
| Melting Point | 300°C (dec) |
| Solubility | Soluble in DMSO. Insoluble in water. |
| Appearance | Off-white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Blue Ice |
| Info Sheet | N5409 Info Sheet PDF |
|---|
Shkoliar NA, Kukhaleva IV, Legon'kov IuA, et al. Study of the therapeutic activity of nocodazole on experimental models of larval alveococcosis. Med Parazitol (Mosk). 2013 Apr-Jun;(2):20-7. PMID: 24003517.
Beswick RW, Ambrose HE, Wagner SD. Nocodazole, a microtubule de-polymerising agent, induces apoptosis of chronic lymphocytic leukaemia cells associated with changes in Bcl-2 phosphorylation and expression. Leuk Res. 2006 Apr;30(4):427-36. PMID: 16162358.
Rahajeng J, Giridharan SS, Naslavsky N, Caplan S. Collapsin response mediator protein-2 (Crmp2) regulates trafficking by linking endocytic regulatory proteins to dynein motors. J Biol Chem. 2010 Oct 15;285(42):31918-31922. PMID: 20801876.
