Description
Nonactinisaneutralcyclicionophorethatactsasanalkalimetalioncarrier,transportingcargosuchasNa+,K+,andNH4+acrosslipidbilayers.Nonactinisamacrotetrolideantibiotic,althoughitdoesnotexhibitantibacterialactivity.NonactinisnaturallyfoundinspeciesofStreptomyces.Thisionophoresuppressesintracellularglycosylationandinhibitsseveraltraffickingpathwaysinvirus-infectedcells.Nonactinalsouncouplesoxidativephosphorylationinmitochondria.
References
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