Nonactin is a neutral cyclic ionophore that acts as an alkali metal ion carrier, transporting cargo such as Na+, K+, and NH4+ across lipid bilayers. Nonactin is a macrotetrolide antibiotic, although it does not exhibit antibacterial activity. Nonactin is naturally found in species of Streptomyces. This ionophore suppresses intracellular glycosylation and inhibits several trafficking pathways in virus-infected cells. Nonactin also uncouples oxidative phosphorylation in mitochondria.
| Cas No. | 6833-84-7 |
|---|---|
| Purity | ≥95%, TLC |
| Formula | C40H64O12 |
| Formula Wt. | 736.93 |
| Melting Point | 145-148°C |
| Solubility | methanol, dichloromethane, ethyl acetate, DMSO |
| Appearance | White to off white powder |
| Store Temp | 4°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | N5652 Info Sheet PDF |
|---|
Lee JM, Kim JG, Kim TH, et al. Nonactin hinders intracellular glycosylation in virus-infected baby hamster kidney cells. Mol Med Rep. 2010 Jan-Feb;3(1):115-9. PMID: 21472209.
Bala S, Kombrabail MH, Prabhananda BS. Effect of phloretin on ionophore mediated electroneutral transmembrane translocations of H(+), K(+) and Na(+) in phospholipid vesicles. Biochim Biophys Acta. 2001 Feb 9;1510(1-2):258-69. PMID: 11342163.
Vareille G, Marion P, Kraus JL, et al. Sodium transport by an ionizable and a neutral mobile carrier: effects of membrane structure on the apparent activation energy. Biochim Biophys Acta. 1993 Feb 23;1146(1):25-37. PMID: 8443224.
Ginsburg H, Stark G. Facilitated transport of di- and trinitrophenolate ions across lipid membranes by valinomycin and nonactin. Biochim Biophys Acta. 1976 Dec 14;455(3):685-700. PMID: 1036715.
