Ofloxacinisasecondgenerationfluoroquinoloneantibiotic.Thiscompoundisoftengivenasatopicaltreatmentforocularandoticinfections.Likeotherfluoroquinolones,ofloxacininhibitsDNAgyraseandtopoisomeraseIV;itexhibitsantibacterialefficacyagainstbothgrampositiveandgramnegativebacteria.UnderUVlight,ofloxacinexhibitsphototoxicity,disputingthemitochondrialmembranepotentialandinducingROS-mediatedDNAdamage.
| CasNo. | 82419-36-1 |
|---|---|
| Purity | ≥98% |
| Formula | C18H20FN3O4 |
| FormulaWt. | 361.37 |
| ChemicalName | 7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylicacid,2,3-dihydro-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-,(+-)- |
| Synonym | Floxin;Ofloxacin;Tarivid |
| MeltingPoint | 250-257°C(dec.) |
| Solubility | Slightlysolubleinwater. |
| Appearance | OffWhiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | O2144MSDSPDF |
|---|---|
| InfoSheet | O2144InfoSheetPDF |
DwivediA,MujtabaSF,YadavN,etal.CellularandmolecularmechanismofofloxacininducedapoptoticcelldeathunderambientUV-Aandsunlightexposure.FreeRADIcRes.2014Mar;48(3):333-46.PMID:24286391.
PantelA,PetrellaS,MatratS,etal.DNAgyraseinhibitionassaysarenecessarytodemonstratefluoroquinoloneresistancesecondarytogyrBmutationsinMycobacteriumtuberculosis.AntimicrobAgentsChemother.2011Oct;55(10):4524-9.PMID:21768507.
DrlicaK,ZhaoX.DNAgyrase,topoisomeraseIV,andthe4-quinolones.MicrobiolMolBiolRev.1997Sep;61(3):377-92.PMID:9293187.
