Ofloxacinisasecondgenerationfluoroquinoloneantibiotic.Thiscompoundisoftengivenasatopicaltreatmentforocularandoticinfections.Likeotherfluoroquinolones,ofloxacininhibitstopoisomeraseIVandDNAgyrase;itexhibitsantibacterialefficacyagainstbothgrampositiveandgramnegativebacteria.UnderUVlight,ofloxacinexhibitsphototoxicity,disputingthemitochondrialmembranepotentialandinducingROS-mediatedDNAdamage.
| CasNo. | 118120-51-7 |
|---|---|
| Purity | ≥98% |
| Formula | C18H20FN3O4•HCl |
| FormulaWt. | 397.83 |
| ChemicalName | 9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicacid |
| Synonym | Ofloxacin;Exocin;Floxil;Oflocet;Tarivid;Visiren |
| MeltingPoint | 250-257°C |
| Solubility | Solubleinwater. |
| Appearance | White/yellowishcrystallinepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | O2145MSDSPDF |
|---|---|
| InfoSheet | O2145InfoSheetPDF |
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PantelA,PetrellaS,MatratS,etal.DNAgyraseinhibitionassaysarenecessarytodemonstratefluoroquinoloneresistancesecondarytogyrBmutationsinMycobacteriumtuberculosis.AntimicrobAgentsChemother.2011Oct;55(10):4524-9.PMID:21768507.
DrlicaK,ZhaoX.DNAgyrase,topoisomeraseIV,andthe4-quinolones.MicrobiolMolBiolRev.1997Sep;61(3):377-92.PMID:9293187.
