ThisproductconsistsofamixtureofoligomycinsA,BandC.Oligomycinsaremacrolideantibioticsthatexhibitantibacterialactivity.OligomycinssuppressoxidativephosphorylationinthemitochondriabyinhibitingK+-activatedcurrentoftheNa+/K+ATPase.Invitro,oligomycinsinhibitIFN-γ-andTNF-α-inducedreductionsintransepithelialresistanceandparacellularpermeABIlity.OligomycinsalsoinhibittheincreaseinexpressionandphosphorylationofMLC,preventingintestinalepithelialbarrierdysfunctioninducedbyinflammatorycytokines.
| CasNo. | 1404-19-9 |
|---|---|
| Purity | ≥97% |
| IUPACName | (5Z,7E,21E)-4-ethyl-11,12,15,19-tetrahydroxy-6"-(2-hydroxypropyl)-5",10,12,14,16,18,20,26,29-nonamethylspiro[24,28-dioxabicyclo[23.3.1]nonacosa-5,7,21-triene-27,2"-oxane]-13,17,23-trione |
| Synonym | Oligomycincomplex |
| MeltingPoint | 84-100°C |
| Solubility | Solubleinethanol,DMSO,acetone. |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | O4533MSDSPDF |
|---|---|
| InfoSheet | O4533InfoSheetPDF |
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