LKT/寡霉素A/O4531/1mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/寡霉素A/O4531/1mg

LKT/寡霉素A/O4531/1mg

商品编号： O4531-1mg

品牌： lktlabs

市场价： ¥1700.00

美元价： 1020.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

ProductIDO4531

CasNo.579-13-5

Purity≥97%,TLC,HPLC

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

OligomycinAisamacrolideantibioticinitiallyproducedbyseveralspeciesofStreptomyces.OligomycinAinhibitsmitochondrialF1F0ATPsynthase,bindingtheF0subunit,inhibitingATPsynthesis.OligomycinAexhibitsantifungalactivityagainstspeciesofAspergillus,Alternaria,Botrytis,andPhytophthora;italsodisplaysantibacterialefficacyagainstavarietyofbacteria.Additionally,thiscompounddisplaysanticancerpotential,asittriggersinositol-requiringenzymea(IRE1)signalingincervicalcancercells,resultinginXBP1splicing,CHOPexpression,DR5upregulation,andultimatelyapoptosis.OligomycinalsoaltersexpressionofBcl-2proteinsingliomacells.

ProductInfo

CasNo.	579-13-5
Purity	≥97%,TLC,HPLC
Formula	C₄₅H₇₄O₁₁
FormulaWt.	791.06
IUPACName	(1R,4S,5E,5"R,6"R,7E,10S,11R,12S,14R,15S,16S,18R,19S,20R,21E,25S,26R,27S,29S)-4-ethyl-11,12,15,19-tetrahydroxy-6"-[(2S)-2-hydroxypropyl]-5",10,12,14,16,18,20,26,29-nonamethylspiro[24,28-dioxABIcyclo[23.3.1]nonacosa-5,7,21-triene-27,2"-oxane]-13,17,23-trione
MeltingPoint	148-152°C
Solubility	SolubleinDMSO,ethanol,acetone.
Appearance	Whitetooffwhitepowder

ShippingandStorage

StoreTemp	4°C
ShipTemp	Ambient

Downloads

MSDS	O4531MSDSPDF
InfoSheet	O4531InfoSheetPDF

References

HeL,JangJH,ChoiHG,etal.OligomycinAenhancesapoptoticeffectofTRAILthroughCHOP-mediateddeathreceptor5expression.MolCarcinog.2013Feb;52(2):85-93.PMID:23335397.

PonnalaS,ChettyC,VeeravalliKK,etal.Metabolicremodelingprecedesmitochondrialoutermembranepermeabilizationinhumangliomaxenograftcells.IntJOncol.2012Feb;40(2):509-18.PMID:22076676.

YangPW,LiMG,ZhaoJY,etal.OligomycinsAandC,majorsecondarymetabolitesisolatedfromthenewlyisolatedstrainStreptomycesdiastaticus.FoliaMicrobiol(Praha).2010Jan;55(1):10-6.PMID:20336498.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂