LKT/PAROMOMYCIN SULFATE/P0370/5 g-免疫在线蚂蚁淘旗下平台

商品详细LKT/PAROMOMYCIN SULFATE/P0370/5 g

LKT/PAROMOMYCIN SULFATE/P0370/5 g

商品编号： P0370-5g

品牌： lktlabs

市场价： ¥3600.00

美元价： 2160.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Product ID P0370

Cas No. 1263-89-4

Purity ≥98%

Description
Product Info
Shipping and Storage
Downloads
References

Description

Paromomycin is an aminoglycoside antibiotic that inhibits cation channels such as PX2X receptors; it exhibits antibacterial, anti-parasitic, and anti-protozoal activities. Paromomycin is clinically used to treat leishmaniasis. This compound inhibits ribosomal recycling, binding to the large subunit of the ribosome and inhibiting interactions between the ribosome and ribosome recycling factor (RRF). Paromomycin also decreases the mitochondrial membrane potential and suppresses protein synthesis (inhibiting translocation of RNA).

Product Info

Cas No.	1263-89-4
Purity	≥98%
Formula	C₂₃H₄₅N₅O₁₄ • H₂SO₄
Formula Wt.	713.71
Chemical Name	D-Streptamine, O-2-amino-2-deoxy-alpha-D-glucopyranosyl-(1->4)-O-(O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1->3)-beta-D-ribofuranosyl-(1->5))-2-deoxy-, sulfate (salt)
IUPAC Name	(2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(2R,3S,4R)-5-[(1R,3S,5R,6S)-3,5-diamino-2-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric acid
Synonym	Aminosidin sulfate; Gabbroral; Aminoxidin; Farmiglucin; Humagel; Humatin; Pargonyl; Sinosid.
Solubility	Soluble in water (>100 mg/mL).

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

Info Sheet	P0370 Info Sheet PDF

References

Bongartz EV, Rettinger J, Hausmann R. Aminoglycoside block of P2X2 receptors heterologously expressed in Xenopus laevis oocytes. Purinergic Signal. 2010 Dec;6(4):393-403. PMID: 21437010.

Jhingran A, Chawla B, Saxena S, et al. Paromomycin: uptake and resistance in Leishmania donovani. Mol Biochem Parasitol. 2009 Apr;164(2):111-7. PMID: 19146886.

Borovinskaya MA, Pai RD, Zhang W, et al. Structural basis for aminoglycoside inhibition of bacterial ribosome recycling. Nat Struct Mol Biol. 2007 Aug;14(8):727-32. PMID: 17660832.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂