PD-325901isananticancerchemotherapeuticMEK1/2andRafinhibitorthatisparticularlyeffectiveagainstcancersharboringB-RaforRasmutationssuchasV600E.PD-325901decreaseslevelsofphosphorylatedERK1/2,cyclinD1,andthymidinekinase1.PD-325901alsoinducescellcyclearrestattheG0/G1phase,inhibitingproliferationinthyroidcancercelllines.Invivo,thiscompounddecreasestumorgrowthandsize.Additionally,PD-325901displaysantiviralbenefit,synergizingwithothertreatmentsincellularmodelsofinfluenzainfection.
| CasNo. | 391210-10-9 |
|---|---|
| Purity | ≥98% |
| Formula | C16H14F3IN2O4 |
| FormulaWt. | 482.19 |
| IUPACName | N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide |
| Synonym | PD0325901 |
| Solubility | SolubleinDMSOat12mg/mL;solubleinethanolat6.3mg/mLwithslightwarming;verypoorlysolubleinwater |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | P1202InfoSheetPDF |
|---|---|
| Brochures | Ras-Raf-MEK-ERKPathwayBooklet |
HaasbachE,HartmayerC,PlanzO.CombinationofMEKinhibitorsandoseltamivirleadstosynergisticantiviraleffectsafterinfluenzaAvirusinfectioninvitro.AntiviralRes.2013May;98(2):319-24.PMID:23523553.
LeytonJ,SmithG,LeesM,etal.NoninvasiveimagingofcellproliferationfollowingmitogenicextracellularkinaseinhibitionbyPD0325901.MolCancerTher.2008Sep;7(9):3112-21.PMID:18790789.
LiuD,XingM.PotentinhibitionofthyroidcancercellsbytheMEKinhibitorPD0325901anditspotentiationbysuppressionofthePI3KandNF-kappaBpathways.Thyroid.2008Aug;18(8):853-64.PMID:18651802.
BrownAP,CarlsonTC,LoiCM,etal.PharmacodynamicandtoxicokineticevaluationofthenovelMEKinhibitor,PD0325901,intheratfollowingoralandintravenousadmiNISTration.CancerChemotherPharmacol.2007Apr;59(5):671-9.PMID:16944149.
