Pefloxacinisasyntheticthirdgenerationfluoroquinoloneantibiotic.Pefloxacindisplaysantibacterialactivity;itinhibitsDNAgyraseandtopoisomeraseIV,suppressingDNAreplicationandtranscription.Additionally,pefloxacininhibitssynthesisofpenicillin-bindingproteins,preventingbacterialcellwallformation.PefloxacinexhibitsmoderateUV-inducedphototoxicity.
| CasNo. | 149676-40-4 |
|---|---|
| Purity | ≥98% |
| Formula | C17H20FN3O3•CH3SO3H•2H2O |
| FormulaWt. | 465.50 |
| ChemicalName | 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylicacidmonomethanesulfonate |
| IUPACName | 1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylicacid |
| Synonym | Pefloxacinemesylate;Peflacine;Peflox |
| Appearance | AlmostWhiteCrystallinePowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | P1622InfoSheetPDF |
|---|
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GrossatoA,FontanaR.SynergyandmechanismofinteractionbetweenpefloxacinandpenicillinGagainstenterococci.NewMicrobiol.1997Jul;20(3):221-5.PMID:9258941.
MoreauNJ,HouotS,Joly-GuillouML,etal.CharacterisationofDNAgyraseandmeasurementofdrugaccumulationinclinicalisolatesofAcinetobacterbaumanniiresistanttofluoroquinolones.JAntimicrobChemother.1996Dec;38(6):1079-83.PMID:9023657.
