Penicillamineisapenicillinderivativethatdoesnotexhibitantibioticactivity.Penicillamineisachelatingcompoundthatisclinicallyusedtotreatrheumatoidarthritis;itexhibitsimmunosuppressive,anti-inflammatory,andanti-allergicactivities.Invitro,penicillaminedecreasesexpressionofIL-1,cross-linkingofcollagen,andactivityofmacrophages;italsodecreasesoverallTcelllevels.Penicillaminealsoinhibitscarboxypeptidasesandseparately,decreasesallergen-inducedproductionofimmunoglobulins.
| CasNo. | 52-67-5 |
|---|---|
| Purity | ≥97% |
| Formula | C5H11NO2S |
| FormulaWt. | 149.21 |
| ChemicalName | 3-Mercapto-D-valine |
| IUPACName | (2S)-2-amino-3-methyl-3-sulfanylbutanoicacid |
| Synonym | Cuprimine;Depen;DMC;D-Penamine;Mercaptyl;Pendramine;Sufortan;Trolovol |
| MeltingPoint | 202-206°C |
| Solubility | Solubleinwater.Slightlysolubleinalcohol.Insolubleinether,acetone,benzene,andcarbontetrachloride. |
| Appearance | WhiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | P1753InfoSheetPDF |
|---|
ChongCR,AuldDS.InhibitionofcarboxypeptidaseAbyD-penicillamine:mechanismandimplicationsfordrugdesign.Biochemistry.2000Jun27;39(25):7580-8.PMID:10858308.
MeyerO.D-penicillamine:mechanismofcellularactionandinducedautoimmunediseases.RevRhumMalOsteoartic.1986Jan;53(1):15-20.PMID:2939541.
CampAV.Penicillamineinthetreatmentofrheumatoidarthritis.ProcRSocMed.1977Feb;70(2):67-9.PMID:859814.
