PenicillinGisahydrophobicβ-lactamantibioticthatdisplaysantibacterialefficacyagainstgrampositivebacteria.PenicillinGismoreactivethanpenicillinVagainstgramnegativebacteriabutexhibitspoororalabsorptionkineticsandmustbeadmiNISTeredbyparenteralinjection.PenicillinGinhibitscellwallsynthesisanddoesnotdisplayeffectiveinhibitionofβ-lactamase-producingbacteria.PenicillinGmayinduceopenchannelorcompetitiveblockofneuromuscularnicotinicacetylcholinereceptors(nAChRs).
| CasNo. | 6130-64-9 |
|---|---|
| Purity | ≥98% |
| Formula | C29H38N4O6S•H2O |
| FormulaWt. | 588.73 |
| ChemicalName | (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(phenoxyacetyl)-amino]-4-Thia-1-azABIcyclo[3.2.0]heptane-2-carboxylicacidwith2-(diethylamino)ethyl4-aminobenzoate(1:1)monohydrate |
| IUPACName | 2-(diethylamino)ethyl4-aminobenzoate;(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid;hydrate |
| Synonym | BenzylpenicillinProcainesalt;Abbocillin;Duracillin;Pfizerpen-AS |
| MeltingPoint | 106-110°C(dec) |
| Solubility | Solubleatabout28oCin:water(6.8mg/mL),methanol(>20mg/mL),ethanol(33mg/mL),andisopropanol(6.5mg/mL). |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | P1852MSDSPDF |
|---|---|
| InfoSheet | P1852InfoSheetPDF |
SunS,SelmerM,AnderssonDI.Resistancetoβ-lactamantibioticsconferredbypointmutationsinpenicillin-bindingproteinsPBP3,PBP4andPBP6inSalmonellaenterica.PLoSOne.2014May8;9(5):e97202.PMID:24810745.
SchlesingerF,KrampflK,HaeselerG,etal.CompetitiveandopenchannelblockofrecombinantnAChRchannelsbydifferentantibiotics.NeuromusculDisord.2004May;14(5):307-12.PMID:15099589.
DemainAL.Productionofbeta-lactamantibioticsanditsregulation.ProcNatlSciCouncRepubChinaB.1991Oct;15(4):251-65.PMID:1815263.
BärH,ZarnackJ.Molecular-BIOLOGicalbasesofthemechanismofactionofpenicillinsandcephasporins.Pharmazie.1970Jan1;25(1):10-22.PMID:4987180.
