Description

Phenyl isothiocyanate (ITC) exhibits antibiotic, anti-angiogenic, anti-inflammatory, antioxidative, anticancer chemotherapeutic, and chemopreventive activities. Phenyl isothiocyanate displays antibacterial efficacy against Escherichia and Staphylococcus, altering membrane function and inducing cell death. In other cellular models, this compound downregulates expression of VEGF and inflammatory cytokines and increases expression of IL-2 and TIMP. Additionally, phenyl isothiocyanate decreases PMA-induced superoxide anion levels, inhibits lipid peroxidation, scavenges hydroxyl radicals, and decreases formation and number of solid tumors in animal models. Like other ITCs, this compound also acts as a phase II enzyme inducer.