LKT/PHENYLHEXYL ISOTHIOCYANATE/P2922/250 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/PHENYLHEXYL ISOTHIOCYANATE/P2922/250 mg

LKT/PHENYLHEXYL ISOTHIOCYANATE/P2922/250 mg

商品编号： P2922-250mg

品牌： lktlabs

市场价： ¥6040.00

美元价： 3624.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

ProductIDP2922

CasNo.133920-06-6

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

IsothiocyanatesarecompoundstypicallyfoundinplantsoftheBrassicaceaefamily,includingbroccoli,cabbage,andrADIsh.Isothiocyanatesarebestknownfortheirantioxidative,anticancerchemotherapeutic,chemopreventive,anti-angiogenic,andantibioticproperties.Invitro,phenhexylisothiocyanate(PHITC)increasescaspase3activityandcleavageofpoly(ADP)-ribosepolymerase(PARP),inducingcaspase-mediatedapoptosisincellularmodels.ThiscompounddecreasesoxidationofcarcinogenNNKandincreasesactivityofNADPH:quinoneoxidoreductaseandglutathioneS-transferaseinvitroandinvivo.PHITCinhibitshistonedeacetylase(HDAC)activity,IL-6receptorproduction,andVEGFexpression;italsoinducesmitochondrialmembranedepolarizationandapoptosisinmyelomacells.Inleukemiacells,PHITCinhibitsexpressionofcyclinandincreasesexpressionofcyclindependentkinase(CDK)inhibitors,inducingapoptosisandinhibitinggrowthofxenograftsofthesecellsinanimals.

ProductInfo

CasNo.	133920-06-6
Purity	≥98%
Formula	C₁₃H₁₇NS
FormulaWt.	219.35
IUPACName	6-isothiocyanatohexylbenzene
Synonym	6-Phenylhexylisothiocyanate;PHITC
Solubility	Solubleinoraganicsolvents.
Appearance	Clearcolorlessliquid

ShippingandStorage

StoreTemp	-20°C
ShipTemp	Ambient

Downloads

InfoSheet	P2922InfoSheetPDF

References

LuQ,LinX,FengJ,etal.Phenylhexylisothiocyanatehasdualfunctionashistonedeacetylaseinhibitorandhypomethylatingagentandcaninhibitmyelomacellgrowthbytargetingcriticalpathways.JHematolOncol.2008Jun9;1:6.PMID:18577263.

LuL,LiuD,MaX,etal.Thephenylhexylisothiocyanateinducesapoptosisandinhibitsleukemiacellgrowthinvivo.OncolRep.2006Dec;16(6):1363-7.PMID:17089062.

MorseMA,EklindKI,HechtSS,etal.Structure-activityrelationshipsforinhibitionof4-(methylnitrosamino)-1-(3-pyridyl)-1-butanonelungtumOrigenesisbyarylalkylisothiocyanatesinA/Jmice.CancerRes.1991Apr1;51(7):1846-50.PMID:2004368.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂