CapsanthinisacarotenoidoriginallyfoundinCapsicumthatexhibitsanticancerandchemopreventiveactivities.Inleukemiacells,capsanthinupregulatesexpressionofPPARγ,Nrf2,andp21,downregulatesexpressionofcyclinD1,inducesapoptosis,andinhibitscellularproliferation.Inanimalmodels,thiscompoundincreaseslevelsofHDLandupregulatesexpressionofApoA5andLCAT.Additionally,capsanthininhibitsTPA-inducedtumordevelopmentinvitroandinvivo.
| CasNo. | 465-42-9 |
|---|---|
| Purity | Colorvalue:100 |
| Formula | C40H56O3 |
| FormulaWt. | 584.87 |
| IUPACName | (2E,4E,6E,8E,10E,12E,14E,16E,18E)-19-[(4R)-4-hydroxy-2,6,6-trimethylcyclohexen-1-yl]-1-[(1R,4S)-4-hydroxy-1,2,2-trimethylcyclopentyl]-4,8,13,17-tetramethylnonadeca-2,4,6,8,10,12,14,16,18-nonaen-1-one |
| Synonym | (3R,3"S,5"R)-3,3"-dihydroxy-β,κ-caroten-6"one;Paprikaextract |
| Solubility | Insolubleinwater.Solubleinoil. |
| Appearance | DarkRedoilliquid |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | C0260MSDSPDF |
|---|---|
| InfoSheet | C0260InfoSheetPDF |
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AizawaK,InakumaT.Dietarycapsanthin,themaincarotenoidinpaprika(Capsicumannuum),altersplasmahigh-densitylipoprotein-cholesterollevelsandhepaticgeneexpressioninrats.BrJNutr.2009Dec;102(12):1760-6.PMID:19646292.
MaokaT,MochidaK,KozukaM,etal.CancerchemopreventiveactivityofcarotenoidsinthefruitsofredpaprikaCapsicumannuumL.CancerLett.2001Oct30;172(2):103-9.PMID:11566483.
