Capsanthin is a carotenoid originally found in Capsicum that exhibits anticancer and chemopreventive activities. In leukemia cells, capsanthin upregulates expression of PPARγ, Nrf2, and p21, downregulates expression of cyclin D1, induces apoptosis, and inhibits cellular proliferation. In animal models, this compound increases levels of HDL and upregulates expression of ApoA5 and LCAT. Additionally, capsanthin inhibits TPA-induced tumor development in vitro and in vivo.
| Cas No. | 465-42-9 |
|---|---|
| Purity | Color value:100 |
| Formula | C40H56O3 |
| Formula Wt. | 584.87 |
| IUPAC Name | (2E,4E,6E,8E,10E,12E,14E,16E,18E)-19-[(4R)-4-hydroxy-2,6,6-trimethylcyclohexen-1-yl]-1-[(1R,4S)-4-hydroxy-1,2,2-trimethylcyclopentyl]-4,8,13,17-tetramethylnonadeca-2,4,6,8,10,12,14,16,18-nonaen-1-one |
| Synonym | (3R,3'S,5'R)-3,3'-dihydroxy-β,κ-caroten-6'one; Paprika extract |
| Solubility | Insoluble in water. Soluble in oil. |
| Appearance | Dark Red oil liquid |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| MSDS | C0260 MSDS PDF |
|---|---|
| Info Sheet | C0260 Info Sheet PDF |
Zhang X, Zhao WE, Hu L, et al. Carotenoids inhibit proliferation and regulate expression of peroxisome proliferators-activated receptor gamma (PPARγ) in K562 cancer cells. Arch Biochem Biophys. 2011 Aug 1;512(1):96-106. PMID: 21620794.
Aizawa K, Inakuma T. Dietary capsanthin, the main carotenoid in paprika (Capsicum annuum), alters plasma high-density lipoprotein-cholesterol levels and hepatic gene expression in rats. Br J Nutr. 2009 Dec;102(12):1760-6. PMID: 19646292.
Maoka T, Mochida K, Kozuka M, et al. Cancer chemopreventive activity of carotenoids in the fruits of red paprika Capsicum annuum L. Cancer Lett. 2001 Oct 30;172(2):103-9. PMID: 11566483.
