Colchicine is an anti-inflammatory anti-mitotic compound originally found in Colchicum; it is clinically used to treat gout. Colchicine binds tubulin and inhibits microtubule polymerization, inhibiting inflammasome activation, cytokine generation, and chemotaxis. Colchicine inhibits neutrophil motility. The anticancer potential of colchicine is limited by its high toxicity.
| Cas No. | 64-86-8 |
|---|---|
| Purity | ≥97% |
| Formula | C22H25NO6 |
| Formula Wt. | 399.44 |
| Chemical Name | N-[(7S)-5,6,7,9-Tetrahydro-1,10,3,10-tetramethoxy-9- oxobenzo[a]heptalen-7-yl]acetamide |
| IUPAC Name | N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide |
| Melting Point | 142-150°C |
| Solubility | Soluble in water (40 mg/mL), ethanol (7 mg/ml), DMSO (14 mg/ml), or chloroform. Insoluble in petr. ether. |
| Appearance | Faintly yellow crystal powder |
| Store Temp | 4°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | C5645 MSDS PDF |
|---|---|
| Info Sheet | C5645 Info Sheet PDF |
Dalbeth N, Lauterio TJ, Wolfe HR. Mechanism of Action of Colchicine in the Treatment of Gout. Clin Ther. 2014 Aug 21. [Epub ahead of print]. PMID: 25151572.
Ching JK, Ju JS, Pittman SK, et al. Increased autophagy accelerates colchicine-induced muscle toxicity. Autophagy. 2013 Dec;9(12):2115-25. PMID: 24184927.
