ConcanavalinAisalectinfoundinCanaveliathatexhibitsimmunostimulatory,pro-fibrotic,andanticancerchemotherapeuticactivities.ConcanavalinAisaplantmitogenthatactivatesTcells;itbindsα-D-mannosylandα-D-glucosylresiduesonsugars,glycoproteins,andglycolipids.ConcanavalinAisusedinresearchtostudycelladhesion.Invivo,concanavalinAinducesfibrosis.Inanimalmodelsofhepatoma,concanavalinAinducesautophagyandcelldeathanddecreasestumornoduleformation.
| CasNo. | 11028-71-0 |
|---|---|
| Purity | ≥98% |
| Synonym | ConA |
| Solubility | Solubleinwater.(Hazy) |
| Appearance | WhitePowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | C5654MSDSPDF |
|---|---|
| InfoSheet | C5654InfoSheetPDF |
WanY,TangMH,ChenXC,etal.InhibitoryeffectofLiposomalquercetinonacutehepatitisandhepaticfibrosisinducedbyconcanavalinA.BrazJMedBiolRes.2014Aug;47(8):655-61.PMID:25098714.
LeiHY,ChangCP.LectinofConcanavalinAasananti-hepatomatherapeuticagent.JBiomedSci.2009Jan19;16:10.PMID:19272170.
DwyerJM,JohnsonC.TheuseofconcanavalinAtostudytheimmunoregulationofhumanTcells.ClinExpImmunol.1981Nov;46(2):237-49.PMID:6461456.
NoonanKD,BurgerMM.TherelationshipofconcanavalinAbindingtolectin-initiatedcellagglutination.JCellBiol.1973Oct;59(1):134-42.PMID:4201706.
