Description
Cryptotanshinone is a quinoid diterpene found in species of Salvia that exhibits anticancer and anti-angiogenic activities. Cryptotanshinone directly inhibits dimerization of STAT3, disrupting STAT3 activation and signaling and inhibiting proliferation in glioma cells. This compound also induces G1/G0 phase cell cycle arrest and inhibits activation of mTOR, p70S6K, and eIF4eBP in rhabdomyosarcoma cells. Additionally, cryptotanshinone downregulates expression of VEGF and inhibits HIF-1α signaling, disturbing tube formation in vitro.
References
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Shin DS, Kim HN, Shin KD, et al. Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells. Cancer Res. 2009 Jan 1;69(1):193-202. PMID: 19118003.
Li W, Li J, Ashok M, et al. A cardiovascular drug rescues mice from lethal sepsis by selectively attentuating a late-acting proinflammatory mediator, high mobility group box 1. J Immunol. 2007 Mar 15;178(6):3856-3864. PMID: 17339485.
Zhang Y, Won SH, Jiang C, et al. Tanshinones fmor Chinese medicinal herb Danshen (Salvia miltiorrhiza Bunge) suppress prostate cancer growth and androgen receptor signaling. Pharm Res. 2012 Jun;29(6):1595-1608. PMID: 22281759.
