LKT/CYCLOPAMINE/C9710/25 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/CYCLOPAMINE/C9710/25 mg

LKT/CYCLOPAMINE/C9710/25 mg

商品编号： C9710-25mg

品牌： lktlabs

市场价： ¥2680.00

美元价： 1608.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDC9710

CasNo.4449-51-8

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

CyclopamineisasteroidaljerveratrumalkaloidfoundinVeratrumthatbindsSmo,inhibitinghedgehog(Shh)signalingpathways.Cyclopamineexhibitsanticanceractivity,decreasesexpressionofGli2andBcl-2,inhibitingproliferationandinducingapoptosisinadenomacellsandneuroblastomacells.CYCLOPAMINESOLUBILITY:EthanolisthebestcyclopaminesolventforBIOLOGicaluse. A2.8%solution(28mg/mL)canbepreparedbysonicatingthecyclopamineinethanol.Avoidoverheating.Storageat-20ºCisrecommended.Ifcyclopaminecrystallizesoutofsolution: uponthawing,themixturecanbeheatedorsonicatedagaintoredissolvethecyclopamine.MethanolandDMSOcanalsobeusedascyclopaminesolvents,butsolubilityinmethanolismuchless(0.7mg/mL). SubstantialheatingisagainneededtoachievesolutionwithmethanolorDMSO.

ProductInfo

CasNo.	4449-51-8
Purity	≥98%
Formula	C₂₇H₄₁NO₂
FormulaWt.	411.62
ChemicalName	Spiro(9H-benzo(a)fluorene-9,2"(3"H)-furo(3,2-b)pyridin)-3-ol,1,2,3,3"a,4,4",5",6,6",6a,6b,7,7",7"a,8,11,11a,11b-octadecahydro-3",6",10,11b-tetramethyl-,(2"R,3S,3"R,3"aS,6"S,6aS,6bS,7"aR,11aS,11bR)-
IUPACName	(3S,3"R,3"aS,6"S,6aS,6bS,7"aR,9R,11aS,11bR)-3",6",10,11b-tetramethylspiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[a]fluorene-9,2"-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-ol
Synonym	11-Deoxyjervine;11-Deoxojervine;HSDB3505.
MeltingPoint	212-215°C
Solubility	Solubleinethanol(≥20mg/mL,methanol(0.7mg/mL).SolubleinDMSO&insolubleinwater.
Appearance	WhiteCrystallineSolid

ShippingandStorage

StoreTemp	-20°C
ShipTemp	Ambient

Downloads

MSDS	C9710MSDSPDF
InfoSheet	C9710InfoSheetPDF
Brochures	CyclopamineFlyer
	HedgehogSignalingFlyer
	WNTBooklet

References

SongM,OuX,XiaoC,etal.HedgehogsignalinginhibitorcyclopamineinducesapoptosisbydecreasingGli2andBcl2expressioninhumansalivarypleomorphicadenomacells.BiomedRep.2013Mar;1(2):325-329.PMID:24648943.

XuL,WangX,WanJ,etal.SonicHedgehogpathwayisessentialforneuroblastomacellproliferationandtumorgrowth.MolCellBiochem.2012May;364(1-2):235-41.PMID:22350753.

StantonBZ,PengLF.Small-moleculemodulatorsoftheSonicHedgehogsignalingpathway.MolBiosyst.2010Jan;6(1):44-54.PMID:20024066.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂