CylindrospermopsinisacyanotoxinthatwasinitiallyproducedbythecyanobacteriumCylindrospermopsisraciborskii.Cylindrospermopsininhibitsproteinandglutathionesynthesisinvitro,inducingoxidativestress,double-strandedDNAbreaks,andcellcyclearrest.Invivo,cylindrospermopsininducesdegenerationandsteatosisintheliver,glomerulopathyinthekidney,andmyofibrolysisandedemaintheheart.Cylindrospermopsinmaybeconsideredcarcinogenic.
| CasNo. | 143545-90-8 |
|---|---|
| Purity | ≥95% |
| Formula | C15H21N5O7S |
| FormulaWt. | 415.42 |
| Solubility | SolubleinMethanolandDMSO |
| Appearance | Clearfilm |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | BlueIce |
| MSDS | C9644MSDSPDF |
|---|---|
| InfoSheet | C9644InfoSheetPDF |
Gutiérrez-PraenaD,RisaldeMA,PichardoS,etal.HistopathologicalandimmunohistochemicalanalysisofTilapia(Oreochromisniloticus)exposedtocylindrospermopsinandtheeffectivenessofN-Acetylcysteinetopreventitstoxiceffects.Toxicon.2013Nov28;78C:18-34.[Epubaheadofprint].PMID:24291634.
Guzmán-GuillénR,PrietoAI,MorenoI,etal.Cyanobacteriumproducingcylindrospermopsincausehistopathologicalchangesatenvironmentallyrelevantconcentrationsinsubchronicallyexposedtilapia(Oreochromisniloticus).EnvironToxicol.2013Sep2.[Epubaheadofprint].PMID:24000190.
AljaŠ,FilipičM,NovakM,etal.Doublestrandbreaksandcell-cyclearrestinducedbythecyanobacterialtoxincylindrospermopsininHepG2cells.MarDrugs.2013Aug21;11(8):3077-90.PMID:23966038.
López-AlonsoH,RubioloJA,VegaF,etal.Proteinsynthesisinhibitionandoxidativestressinducedbycylindrospermopsinelicitapoptosisinprimaryrathepatocytes.ChemResToxicol.2013Feb18;26(2):203-12.PMID:23270326.
