Cytochalasin A is a mycotoxin actin polymerization inhibitor initially produced by species of Aspergillus. Cytochalasin A inhibits platelet-mediated adhesion of tumor cells to the endothelial matrix, displaying potential anticancer benefit. Cytochalasin A also inhibits Kv1.5 K+ channels in vitro. This compound’s disruption of actin polymerization also prevents phagocytosis in macrophages.
| Cas No. | 14110-64-6 |
|---|---|
| Purity | ≥98% |
| Formula | C29H35NO5 |
| Formula Wt. | 477.60 |
| Melting Point | 193-195°C |
| Appearance | White Powder |
| Store Temp | 4°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | C9878 Info Sheet PDF |
|---|
Choi BH, Park JA, Kim KR, et al. Direct block of cloned hKv1.5 channel by cytochalasins, actin-disrupting agents. Am J Physiol Cell Physiol. 2005 Aug;289(2):C425-36. PMID: 15800051.
Menter DG, Sloane BF, Steinert BW, et al. Platelet enhancement of tumor cell adhesion to subendothelial matrix: role of platelet cytoskeleton and platelet membrane. J Natl Cancer Inst. 1987 Nov;79(5):1077-90. PMID: 3479634.
