CytochalasinEisamycotoxinactinpolymerizationinhibitorinitiallyproducedbyspeciesofAspergillus.CytochalasinEincreaseslevelsofIL-8,ICAM-1,andCD-54invitro.CytochalasinEalsoexhibitsanticancerchemotherapeuticandanti-angiogenicactivities.Inendothelialcells,cytochalasinEinhibitscellproliferationandFGF-stimulatedangiogenesis.Insimilaranimalmodels,thiscompoundinhibitslungtumorgrowth.
| CasNo. | 36011-19-5 |
|---|---|
| Purity | ≥98% |
| Formula | C28H33NO7 |
| FormulaWt. | 495.57 |
| MeltingPoint | 206°C(dec) |
| Appearance | WhitePowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | C9882InfoSheetPDF |
|---|
IkewakiN,YamadaA,InokoH.DepolymerizationofactinfilamentbycytochalasinEinducesinterleukin-8productionandup-regulatesCD54intheHeLaepithelialcellline.MicrobiolImmunol.2003;47(10):775-83.PMID:14605444.
UdagawaT,YuanJ,PanigrahyD,etal.CytochalasinE,anepoxidecontainingAspergillus-derivedfungalmetabolite,inhibitsangiogenesisandtumorgrowth.JPharmacolExpTher.2000Aug;294(2):421-7.PMID:10900214.
GanY,AuJL,LuJ,etal.Antiproliferativeandcytotoxiceffectsofgeldanamycin,cytochalasinE,suraminandthiacetazoneinhumanprostatexenografttumorhistocultures.PharmRes.1998Nov;15(11):1760-6.PMID:9834000.
