LKT/DAIDZEIN/D0032/5 g-免疫在线蚂蚁淘旗下平台

商品详细LKT/DAIDZEIN/D0032/5 g

LKT/DAIDZEIN/D0032/5 g

商品编号： D0032-5g

品牌： lktlabs

市场价： ¥6600.00

美元价： 3960.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

ProductIDD0032

CasNo.486-66-8

Purity≥97%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Daidzeinisaphytoestrogenandisoflavoneinitiallyfoundinvariousplantsources,includingsoybeans.Daidzeinexhibitspro-fibrotic,anti-inflammatory,anticancerchemotherapeutic,neuroprotective,immunomodulatory,anti-osteoporotic,anti-resorptive,anti-obesity,andantioxidativeactivities.DaidzeinincreasescollagensynthesisandinhibitscollagendegradationinfibroblastsbyactivatingTGF-β/Smadsignaling.Invivo,daidzeindecreasesTNF-α-inducedlunginflammation,expressionofCxcl2,activationofNF-κB,andactivityofPARP-1.Inhepaticcancercells,daidzeininducesapoptosis,increasescytochromecreleaseandactivationofcaspases3and9,anddecreasescellularproliferation.Inotherinvitromodels,daidzeinincreasesneuritegrowthbyincreasingactivityofPKC,ERK,andSrc.Invivo,daidzeindecreasesovariectomy-inducedincreasesinCD4+Tcelllevels;italsoincreasesCD28+Tcelllevels,decreasesRANKLexpression,andsuppressesosteoclastformation.ThiscompoundinhibitsADIpogenicdifferentiationbyincreasinglipolysisinvitro.Invivo,daidzeinincreaseslevelsofsuperoxidedismutase,catalase,glutathione,glutathioneperoxidase,andglutathione-S-transferase,inhibitingDMBA-inducedbreastcancerdevelopment.

ProductInfo

CasNo.	486-66-8
Purity	≥97%
Formula	C₁₅H₁₀O₄
FormulaWt.	254.24
ChemicalName	7-Hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
IUPACName	7-hydroxy-3-(4-hydroxyphenyl)chromen-4-one
Synonym	7,4"-Dihydroxyisoflavone
MeltingPoint	315-325°C(dec.)
Solubility	Solubleinethanolorether.
Appearance	SliightYellowCrystalPowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

MSDS	D0032MSDSPDF
InfoSheet	D0032InfoSheetPDF
Brochures	NaturalProductsBooklet

References

LiHY,PanL,KeYS,etal.Daidzeinsuppressespro-inflammatorychemokineCxcl2transcriptioninTNF-α-stimulatedmurinelungepithelialcellsviadepressingPARP-1activity.ActaPharmacolSin.2014Apr;35(4):496-503.PMID:24632845.

ZhaoD,ShiY,DangY,etal.DaidzeinstimulatescollagensynthesisbyactivatingtheTGF-β/smadsignalpathway.AustralasJDermatol.2014Mar19.[Epubaheadofprint].PMID:24645968.

ParkHJ,JeonYK,YouDH,etal.Daidzeincausescytochromec-mediatedapoptosisviatheBcl-2familyinhumanhepaticcancercells.FoodChemToxicol.2013Oct;60:542-9.PMID:23959101.

YanagiharaK,TakigahiraM,MiharaK,etal.Inhibitoryeffectsofisoflavonesontumorgrowthandcachexiainnewlyestablishedcachecticmousemodelscarryinghumanstomachcancers.NutrCancer.2013;65(4):578-89.PMID:23659450.

YangSH,LiaoCC,ChenY,etal.DaidzeininducesneuritogenesisinDRGneuronalcultures.JBiomedSci.2012Aug29;19:80.PMID:22931352.

TyagiAM,SrivastavaK,SharanK,etal.DaidzeinpreventstheincreaseinCD4+CD28nullTcellsandBlymphopoesisinovariectomizedmice:akeymechanismforanti-osteoclastogeniceffect.PLoSOne.2011;6(6):e21216.PMID:21731677.

KimMH,ParkJS,SeoMS,etal.GeNISTeinanddaidzeinrepressadipogenicdifferentiationofhumanadiposetissue-derivedmesenchymalstemcellsviaWnt/β-cateninsignallingorlipolysis.CellProlif.2010Dec;43(6):594-605.PMID:21039998.

MishraP,KarA,KaleRK.PreventionofchemicallyinducedmammarytumOrigenesisbydaidzeininpre-pubertalrats:theroleofperoxidativedamageandantioxidativeenzymes.MolCellBiochem.2009May;325(1-2):149-57.PMID:19214712.

YokoyamaS,NiwaT,OsawaT,SuzukiT.CharacterizationofanO-desmethylangolensin-producingbacteriumisolatedfromhumanfeces.ArchMicrobiol.2010Jan;192(1):15-22.PMID:19904524.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂