PsoralenisafuranocoumarincompoundoriginallyfoundinPsoraleacoryfoliathatexhibitsanti-angiogenicactivity.PsoraleniscurrentlyusedtotreatpsoriasiswiththeadditionalofUVAlight.PsoraleninhibitsangiogenesisandinducesG0/G1phasecellcyclearrestandapoptosisinendothelialcells.ThiscompoundalsoinhibitstopoisomeraseIandinducesDNAinterstrandcrosslinksandmonoadducts,displayingcarcinogenicpotentialaswell.
| CasNo. | 66-97-7 |
|---|---|
| Purity | ≥98% |
| Formula | C11H6O3 |
| FormulaWt. | 186.16 |
| IUPACName | furo[3,2-g]chromen-7-one |
| Synonym | Ficusin |
| MeltingPoint | 163-164°C |
| Solubility | Solubleinethanol(10mg/ml),ethylacetate,acetone,andwater(1.93mg/mlat25°C). |
| Appearance | WhiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | P7358InfoSheetPDF |
|---|
ChopraB,DhingraAK,DharKL.PsoraleacorylifoliaL.(Buguchi)-folkloretomodernevidence:review.Fitoterapia.2013Oct;90:44-56.PMID:23831482.
DiwanR,MalpathakN.Furanocoumarins:noveltopoisomeraseIinhibitorsfromRutagraveolensL.BioorgMedChem.2009Oct1;17(19):7052-5.PMID:19736019.
DerheimerFA,HicksJK,PaulsenMT,etal.Psoralen-inducedDNAinterstrandcross-linksblocktranscriptionandinducep53inanataxia-telangiectasiaandrad3-related-dependentmanner.MolPharmacol.2009Mar;75(3):599-607.PMID:19064630.
DengH,YanCL,HuY,etal.Photochemotherapyinhibitsangiogenesisandinducesapoptosisofendothelialcellsinvitro.PhotodermatolPhotoimmunolPhotomed.2004Aug;20(4):191-9.PMID:15238097.
