Ochratoxin A is a mycotoxin initially produced by Aspergillus and Penicillum that exhibits carcinogenic, neurotoxic, and pro-fibrotic activities. Ochratoxin A is occasionally found as a contaminant in food and livestock feed. In vivo, ochratoxin A inhibits glial cell proliferation, induces kidney damage and collagen formation, and potentially increases the development of cancerous formations.
| Cas No. | 303-47-9 |
|---|---|
| Purity | ≥98% |
| Formula | C20H18ClNO6 |
| Formula Wt. | 403.82 |
| Chemical Name | (R)-N-[(5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1- oxo-1H-2benzopyran-7-yl)carbonyl]-L-phenylalanine |
| IUPAC Name | (2S)-2-[[(3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydroisochromene-7-carbonyl]amino]-3-phenylpropanoic acid |
| Synonym | Phenylalanine - ochratoxin A |
| Melting Point | 169°C |
| Solubility | Soluble in methanol. |
| Appearance | White to off white crystals |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | O0829 Info Sheet PDF |
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Hennemeier I, Humpf HU, Gekle M, et al. Role of microRNA-29b in the ochratoxin A-induced enhanced collagen formation in human kidney cells. Toxicology. 2014 Oct 3;324:116-22. PMID: 25091173.
Paradells S, Rocamonde B, Llinares C, et al. Neurotoxic effects of ochratoxin A on the subventricular zone of adult mouse brain. J Appl Toxicol. 2014 Sep 25. [Epub ahead of print]. PMID: 25256750.
Qi X, Yu T, Zhu L, et al. Ochratoxin A induces rat renal carcinogenicity with limited induction of oxidative stress responses. Toxicol Appl Pharmacol. 2014 Sep 8. [Epub ahead of print]. PMID: 25218026.
Wu X, Hu J, Zhu B, et al. Aptamer-targeted magnetic nanospheres as a solid-phase extraction sorbent for determination of ochratoxin A in food samples. J Chromatogr A. 2011 Oct 14;1218(41):7341-7346. PMID: 21890142.
