Description
Okadaicacidisadiarrheticshellfishtoxininitiallyproducedbydinoflagellatesandseasponges;itexhibitsneurotoxicandanticanceractivities.Okadaicacidinhibitsproteinphosphatases1and2A(PP1,PP2A).InanimalmodelsofAlzheimer’sdisease,okadaicacidincreasesphosphorylationoftauprotein.InADIpocytes,thiscompoundstimulateslipolysisbyincreasingphosphorylationofperilipinAandB.InTcellleukemiacells,okadaicacidinducesG1phasecellcyclearrest,decreasesexpressionofcyclinD2,CDK4,CDK6,Bcl-2,Bcl-xl,andXIAP,increasesexpressionofp21andp27,activatescaspases,andinhibitscellgrowth.
References
KamatPK,RaiS,SwarnkarS,etal.MolecularandCellularMechanismofOkadaicAcid(OKA)-InducedNeurotoxicity:ANovelToolforAlzheimer"sDiseaseTherapeuticApplication.MolNeurobiol.2014Apr8.[Epubaheadofprint].PMID:24710687.
ChangNC,LinAC,HsuCC,etal.OkadaicAcid,aBioactiveFattyAcidfromHalichondriaokadai,StimulatesLipolysisinRatAdipocytes:ThePivotalRoleofPerilipinTranslocation.EvidBasedComplementAlternatMed.2013;2013:545739.PMID:24319476.
MoriN,IshikawaC,UchiharaJN,etal.Proteinphosphatase2AasapotentialtargetfortreatmentofadultTcellleukemia.CurrCancerDrugTargets.2013Oct;13(8):829-42.PMID:24015987.
