LKT/齐墩果酸/O4417/1克-免疫在线蚂蚁淘旗下平台

商品详细LKT/齐墩果酸/O4417/1克

LKT/齐墩果酸/O4417/1克

商品编号： O4417-1g

品牌： lktlabs

市场价： ¥8260.00

美元价： 4956.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDO4417

CasNo.508-02-1

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

OleanolicacidisatriterpenoidoriginallyfoundinVignaangularisandTrigonellafoenum-graecum.Oleanolicacidexhibitsanticancer,anti-inflammatory,anti-allergic,anti-resorptive,andanti-osteoporoticactivities.Inhypertrophicscarfibroblasts,oleanolicacidinducesmitochondria-dependentapoptosisthroughtheactivationofp38MAPKandJNKandincreasesincaspaseexpression.Inmelanomacells,oleanolicaciddecreasescellviABIlitybyinducingcaspase3-mediatedapoptosisandinhibitingactivityofEGFR.Additionally,inanimalmodels,thiscompoundinhibitseosinophilinfiltration,airwayinflammation,andproductionofIL-5,IL-13,IL-17,andIgE;thisisthroughtobemediatedbyupregulationofFoxp3anddownregulationofGATA-3andRORγt.Inbonemarrowmacrophages,oleanolicacidinhibitsRANKL-inducedosteoclastdifferentiationandmatureosteoclastdifferentiation;italsoinhibitsLPS-inducedboneerosioninanimalmodels.

ProductInfo

CasNo.	508-02-1
Purity	≥98%
Formula	C₃₀H₄₈O₃
FormulaWt.	456.71
IUPACName	(4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylicacidInChI:InChI=1S/C30H48O3/c1-25(2)14-16-30(24(32)33)17-15-28(6)19(20(30)18-25)8-9-22-27(5)12-11-23(31)26(3,4)21(27)10-13-29(22,28)7/h8,20-23,31H,9-18H2,1-7H3,(H,32,33)/t20-,21-,22+,23-,27-,28+,29+,30-/m0/s1
Synonym	AstrantiageninC;Caryophyllin;GiganteumgeninC;Oleanicacid;VirgaureageninB
MeltingPoint	310°C
Solubility	Solubleinether,acetone,chloroformorethanol.Insolubleinwater.
Appearance	WhiteCrystalPowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

InfoSheet	O4417InfoSheetPDF

References

ChenJY,ZhangL,ZhangH,etal.Triggeringofp38MAPKandJNKSignalingisImportantforOleanolicAcid-InducedApoptosisviatheMitochondrialDeathPathwayinHypertrophicScarFibroblasts.PhytotherRes.2014Apr6.[Epubaheadofprint].PMID:24706573.

GhoshS,BishayeeK,Khuda-BukhshAR.OleanolicacidisolatedfromethanolicextractofPhytolaccadecandrainducesapoptosisinA375skinmelanomacells:drug-DNAinteractionandsignalingcascade.JIntegrMed.2014Mar;12(2):102-14.PMID:24666676.

KimJY,CheonYH,OhHM,etal.OleanolicacidacetateinhibitsosteoclastdifferentiationbydownregulatingPLCγ2-Ca(2+)-NFATc1signaling,andsuppressesbonelossinmice.Bone.2014Mar;60:104-11.PMID:24361669.

KimSH,HongJH,LeeYC.Oleanolicacidsuppressesovalbumin-inducedairwayinflammationandTh4-mediatedallergicasthmabymodulatingthetranscriptionfactorsT-bet,GATA-3,RORγtandFoxp3inasthmaticmice.IntImmunopharmacol.2014Feb;18(2):311-24.PMID:24374304.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂