LKT/PACLITAXEL, FROM TAXUS YUNNANENSIS/P0092/5 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/PACLITAXEL, FROM TAXUS YUNNANENSIS/P0092/5 mg

LKT/PACLITAXEL, FROM TAXUS YUNNANENSIS/P0092/5 mg

商品编号： P0092-5mg

品牌： lktlabs

市场价： ¥1440.00

美元价： 864.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

ProductIDP0092

CasNo.33069-62-4

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

PaclitaxelisaditerpenecompoundfoundinTaxusyunnanensisthatexhibitsanticancerchemotherapeuticandanti-angiogenicactivities.Paclitaxelinducestubulinpolymerization,formingstablebutnonfunctionalmicrotubules;itinhibitsshorteningofmicrotubuleleADIngedges,decreasesperipheralmicrotubuleformation,andaltersmorphologyoffocaladhesions,preventingcellmigrationandproliferation.Paclitaxelalsodysregulatestheepithelial-to-mesenchymal(EMT)transition,inducingtransitionofcancercellsintobenignfibroblast-likecells.Invitro,paclitaxelinducescaspase8-mediatedapoptosisthroughtheassociationofcaspase8’sdeatheffectordomainwithmicrotubules.

ProductInfo

CasNo.	33069-62-4
Purity	≥98%
Formula	C₄₇H₅₁NO₁₄
FormulaWt.	853.91
Synonym	Taxol;TaxolA;Paxene
MeltingPoint	213-217°C
Solubility	Insolubleinwater(4mg/L).Solubleinethanol(18mg/mL)orDMSO(50mg/ml)
Appearance	WhiteCrystallinePowder

ShippingandStorage

StoreTemp	-20°C
ShipTemp	Ambient

Downloads

MSDS	P0092MSDSPDF
InfoSheet	P0092InfoSheetPDF

References

KamathK,SmiyunG,WilsonL,etal.Mechanismsofinhibitionofendothelialcellmigrationbytaxanes.Cytoskeleton(Hoboken).2013Oct23.[Epubaheadofprint].PMID:24155271.

CaltováK,CervinkaM.AntiproliferativeeffectsofselectedchemotherapeuticsinhumanovariancancercelllineA2780.ActaMedica(HradecKralove).2012;55(3):116-24.PMID:23297519.

JiaL,ZhangS,YeY,etal.Paclitaxelinhibitsovariantumorgrowthbyinducingepithelialcancercellstobenignfibroblast-likecells.CancerLett.2012Dec30;326(2):176-82.PMID:22902993.

MielgoA,TorresVA,ClairK,etal.Paclitaxelpromotesacaspase8-mediatedapoptosisthroughdeatheffectordomainassociationwithmicrotubules.Oncogene.2009Oct8;28(40):3551-62.PMID:19668227.

BottaM,ForliS,MagnaniM,etal.MolecularmodelingapproachestostudythebindingmodeontubulinofmicrotubuledestABIlizingandstabilizingagents.TopCurrChem.2009;286:279-328.PMID:23563616.

ChenYQ,ZhuWH,WuYQ,etal.EffectsofcultureconditionsoncallusgrowthandtaxolformationofTaxusyunnanensisChengetL.K.Fu.ZhongguoZhongYaoZaZhi.2000May;25(5):269-72.PMID:12512447.

KumarN.Taxol-inducedpolymerizationofpurifiedtubulin.Mechanismofaction.JBiolChem.1981Oct25;256(20):10435-41.PMID:6116707.

YuYH,KimE,ParkDE,etal.Cationicsolidlipidnanoparticlesforco-deliveryofpaclitaxelandsiRNA.EurJPharmBiopharm.2012Feb;80(2):268-273.PMID:22108492.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂