Description
PaeoniflorinisfoundinPaeonia;itexhibitsanti-inflammatory,antioxidative,neuromodulatory,antidepressant,analgesic,andanticancerchemotherapeuticactivities.InanimalmodelsofDSS-inducedcolitis,paeoniflorindecreasesexpressionoftoll-likereceptor4(TLR4),inhibitsproductionofIL-6andTNF-α,andsuppressesactivityofmyeloperoxidase.PaeoniflorinalsoscavengesROSbyinhibitingexpressionofNADPHoxidase,decreasingoxidativestressinanimalmodels.PaeoniflorindecreasesimmobilityinanimalsundergoingtheforcedswimtestandtailsUSPensiontestandincreaseslevelsof5-HTinthehippocampus.Additionally,paeoniflorininhibitscellandtumorgrowthandinducesG1phasecellcyclearrestincellularandanimalmodelsofcolorectalcancer.ThiscompoundalsodecreaseshyperalgesiainanimalmodelsandinhibitsL-typevoltage-gatedCa2+channels.
References
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