LKT/PARTHENOLIDE/P0270/25 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/PARTHENOLIDE/P0270/25 mg

LKT/PARTHENOLIDE/P0270/25 mg

商品编号： P0270-25mg

品牌： lktlabs

市场价： ¥1440.00

美元价： 864.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDP0270

CasNo.20554-84-1

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

ParthenolideisasesquiterpenelactonefoundinTanacetumthatexhibitsanticancerchemotherapeutic,anti-metastatic,anti-angiogenic,anti-inflammatory,andantinociceptiveactivities.ParthenolideactsasapartialagoNISTattransientreceptorpotentialankyrin1(TRPA1)channelsanddesensitizesthem,preventingreleaseofcalcitoningene-relatedpeptide(CGRP).Additionally,parthenolideinhibitsATPaseactivityofNLRP3andproteaseactivityofcaspase1.Inmultiplemyelomacells,parthenolidedecreasesexpressionofNF-κB,VEGF,andIL-6andincreasesexpressionofIκBkinase,inhibitingcellmigrationandtubuleformation.Innon-smallcelllungcancer(NSCLC)cells,parthenolidedecreaseslevelsofMCL-1andincreaseslevelsofMAIP-1,triggeringERstressandinducingcellcyclearrestandapoptosis.Inbreastcancercells,thiscompoundactivatesNADPHoxidaseandincreasesROSgeneration,increasinglevelsofp-JNKanddownregulatingNF-κB,VEGF,andmatrixmetalloproteinases2and9(MMP2/9);invivo,parthenolideinhibitstumorgrowthandmetastasis.

ProductInfo

CasNo.	20554-84-1
Purity	≥98%
Formula	C₁₅H₂₀O₃
FormulaWt.	248.32
MeltingPoint	112-115°C
Solubility	DMSO(100mg/ml),Ethanol(20mg/ml),Dichloromethane.
Appearance	WhiteCrystals

ShippingandStorage

StoreTemp	4°C
ShipTemp	Ambient

Downloads

MSDS	P0270MSDSPDF
InfoSheet	P0270InfoSheetPDF
Brochures	TRPChannelModulatorFlyer

References

ZhaoX,LiuX,SuL.ParthenolideinducesapoptosisviaTNFRSF10BandPMAIP1pathwaysinhumanlungcancercells.JExpClinCancerRes.2014Jan6;33(1):3.PMID:24387758.

MaterazziS,BenemeiS,FusiC,etal.ParthenolideinhibitsnociceptionandneurogenicvasodilatationinthetrigeminovascularsystembytargetingtheTRPA1channel.Pain.2013Dec;154(12):2750-8.PMID:23933184.

D"AnneoA,CarlisiD,LauricellaM,etal.ParthenolidegeneratesreactiveoxygenspeciesandautophagyinMDA-MB231cells.Asolubleparthenolideanalogueinhibitstumourgrowthandmetastasisinaxenograftmodelofbreastcancer.CellDeathDis.2013Oct31;4:e891.PMID:24176849.

JulianaC,Fernandes-AlnemriT,WuJ,etal.Anti-inflammatorycompoundsparthenolideandBay11-7082aredirectinhibitorsoftheinflammasome.JBiolChem.2010Mar26;285(13):9792-802.PMID:20093358.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂