PaxillineisaneuroactivemycotoxininitiallyproducedbyspeciesofPenicillumandAspergillus.Invitroandinvivo,paxillineinhibitsCa2+/voltage-sensitiveK+(BK)channels.Paxillinealsocompetitivelyinhibitssarco/endoplasmicreticulumCa2+ATPase(SERCA),preventingCa2+releaseandphosphoenzymeformation.
| CasNo. | 57186-25-1 |
|---|---|
| Purity | ≥98% |
| Formula | C27H33NO4 |
| FormulaWt. | 435.56 |
| MeltingPoint | 252-269°C |
| Solubility | Acetone,Methanol,andDMSO. |
| Appearance | WhitePowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | P0392MSDSPDF |
|---|---|
| InfoSheet | P0392InfoSheetPDF |
BorchertGH,HlaváčkováM,KolářF.PharmacologicalactivationofmitochondrialBK(Ca)channelsprotectsisolatedcardiomyocytesagainstsimulatedreperfusion-inducedinjury.ExpBiolMed(Maywood).2013Feb;238(2):233-41.PMID:23576804.
BilmenJG,WoottonLL,MichelangeliF.Themechanismofinhibitionofthesarco/endoplasmicreticulumCa2+ATPasebypaxilline.ArchBiochemBiophys.2002Oct1;406(1):55-64.PMID:12234490.
