Description
PeimineisasteroidalalkaloidfoundinavarietyofspeciesoftheFritillariaplant;itexhibitsanti-inflammatoryactivityandactsasanexpectorantandanti-tussiveincoughmedications.Peimine’santi-tussiveactivitymayresultfromnegativepotentiationoftransientreceptorpotentialchannelsTRPV1andTRPA1invitro.Peimineinhibitscoughfrequencyandcoughlatencyinanimalmodels.Additionally,peiminebindstheDNAduplex,inhibitsproductionofpro-inflammatorycytokineslikeTNF-α,IL-6,andIL-1β,anddecreasesexpressionofIκBkinase,JNK,andp38.
References
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