PeiminineisasteroidalalkaloidfoundinavarietyofspeciesoftheFritillariaplant;itactsasanexpectorantandanti-tussiveincoughmedications.PeiminineincreasescAMP,inhibitsM2mAChRs,andmaynegativelymodulatetransientreceptorpotentialchannelsTRPV1andTRPA1invitro.Peimininealsodisplaysanti-inflammatoryactivityinanimalmodelsofpulmonaryfibrosis,decreasinglevelsofIFN-γ,TGF-β,NF-κB,ERK1/2,andFasL.
| CasNo. | 18059-10-4 |
|---|---|
| Purity | ≥98% |
| Formula | C27H43NO3 |
| FormulaWt. | 429.64 |
| Synonym | Imperialine |
| Appearance | WhitePowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | P1635MSDSPDF |
|---|---|
| InfoSheet | P1635InfoSheetPDF |
GuoH,JiF,LiuB,etal.Peiminineamelioratesbleomycin-inducedacutelunginjuryinrats.MolMedRep.2013Apr;7(4):1103-10.PMID:23404624.
ZhangY,SreekrishnaK,LinY,etal.Modulationoftransientreceptorpotential(TRP)channelsbyChineseherbalextracts.PhytotherRes.2011Nov;25(11):1666-70.PMID:21432926.
ZhouY,JiH,LinBQ,etal.TheeffectsoffivealkaloidsfromBulbusFritillariaeontheconcentrationofcAMPinHEKcellstransfectedwithmuscarinicM(2)receptorplasmid.AmJChinMed.2006;34(5):901-10.PMID:17080553.
