PenitremAisaneuroactivemycotoxininitiallyproducedbyspeciesofPenicillum.PenitremAexhibitstremorgenicactivity.Invitroandinvivo,penitremAinhibitsCa2+/voltage-sensitiveK+(BK)channels.PenitremAalsopotentiatesGABA-AreceptorfunctionintheforebrainandinhibitsuptakeofGABAandglutamateintosynaptosomes.Additionally,penitremAmaydisruptlearningacquisitionbutnotmemoryortaskperformanceinanimalmodelsexaminingpassiveavoidancetesting.
| CasNo. | 12627-35-9 |
|---|---|
| Purity | ≥98% |
| Formula | C37H44ClNO6 |
| FormulaWt. | 634.20 |
| Synonym | TremortinA |
| MeltingPoint | 224-230°C(dec) |
| Solubility | Acetone,Methanol,andDMSO. |
| Appearance | WhitePowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | P1952InfoSheetPDF |
|---|
Moldes-AnayaA,RundbergetT,FæsteCK,etal.NeurotoxicityofPenicilliumcrustosumsecondarymetabolites:tremorgenicactivityoforallyadmiNISTeredpenitremAandthomitremAandEinmice.Toxicon.2012Dec15;60(8):1428-35.PMID:23085423.
AsanoS,BratzIN,BerwickZC,etal.PenitremAasatoolforunderstandingtheroleoflargeconductanceCa(2+)/voltage-sensitiveK(+)channelsinvascularfunction.JPharmacolExpTher.2012Aug;342(2):453-60.PMID:22580348.
Moldes-AnayaAS,FonnumF,EriksenGS,etal.Invitroneuropharmacologicalevaluationofpenitrem-inducedtremorgenicsyndromes:importanceoftheGABAergicsystem.NeuRochemInt.2011Dec;59(7):1074-81.PMID:21924313.
DeschauxO,BizotJC.EffectsofpenitremAonrat"sperformancesinpassiveavoidanceandMorriswatermazetests.Mycopathologia.1997;138(2):99-104.PMID:9433810.
