Description
Perillylalcoholisamonoterpenefoundinvariousplantandfruitsources.Perillylalcoholexhibitsneuroprotective,antioxidative,anti-inflammatory,anti-asthma,anti-allergic,immunomodulatory,anticancerchemotherapeutic,andchemopreventiveactivities.Inanimalmodelsofstroke,perillylalcoholinhibitsneurologicaldeficits,improvesmotorcoordination,increaseslevelsofglutathione,catalase,glutathionereductase,andglutathioneperoxidase,decreasesinfarctvolume,andsuppressesexpressionofIL-1β,TNF-α,IL-6,COX-2,iNOS,andNF-κB.Perillylalcoholinhibitsfarnesyltransferase,geranylgeranyltransferase,telomerase,andNa+/K+ATPases.InanimalmodelsofOVA-inducedallergy,perillylalcoholsuppressesproliferationofantigen-stimulatedimmunecells,decreasingtheallergicresponse.ThiscompoundshowsclinicalbenefitinthetreatmentofglioblastomaandinducesG1phasecellcyclearrestandincreasesexpressionofp15andp21incellularmodelsofcancer.Additionally,perillylalcoholpreventsUV-andDMBA-induceddevelopmentofskincancerinvivo.
References
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