LKT/PICEATANNOL/P3209/100 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/PICEATANNOL/P3209/100 mg

LKT/PICEATANNOL/P3209/100 mg

商品编号： P3209-100mg

品牌： lktlabs

市场价： ¥10900.00

美元价： 6540.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDP3209

CasNo.10083-24-6

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

PiceatannolisapolyphenolichydroxystilbenederivativeofresveratrolwithincreasedbioavailABIlityandbioactivitycomparedtoitsparentcompound.Piceatannolexhibitspro-angiogenic,anticancer,antioxidative,andanti-obesityproperties.PiceatannoldirectlyinhibitsHIF-prolylhydroxylase-2(HPH-2),increasinglevelsofHIF-1α,VEGF,andhemeoxygenase-1(HO1).Whencomplexedwithcopper(II),thepiceatannol-CucomplexincreasesROSlevelsanddamagesDNA.Additionally,piceatannolsuppressesnucleartranslocationofp65andp50,preventingactivationofNF-κBanddownregulatingexpressionofmatrixmetalloproteinase9(MMP9).PiceatannolalsodownregulatesphosphorylationofAktinprostatecancercells.Inotherinvitromodels,thiscompoundincreaseslevelsoftissueinhibitorofmetalloproteinase2(TIMP2)andinhibitsphosphorylationofSTAT3;italsodownregulatesBcl-xlandinhibitsphosphorylationofJNK.Inprostatecancercells,piceatannoldecreaseslevelsofcyclinsAandD1andalsodecreasescyclin-dependentkinase2and4(CDK2,CDK4)activity,inhibitingcellgrowth.ThehydroxylgroupsonpiceatannolfunctionasrADIcalscavengers,preventingaccumulationofROSandRNS.Thiscompoundnoncompetitivelyinhibitstheinsulinreceptor(IR),preventingphosphorylationofthereceptor,IRsubstrate-1andAkt,inhibitingAdipogenesisofpreadipocytes;itmayalsodirectlyinhibitPI3KandJAK1.

ProductInfo

CasNo.	10083-24-6
Purity	≥98%
Formula	C₁₄H₁₂O₄
FormulaWt.	244.24
ChemicalName	3,3’,4,5’-Tetrahydroxy-trans-stilbene
IUPACName	4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,2-diol
Solubility	DMSO(20mg/ml),Ethanol(10mg/ml)
Appearance	LightPinkPowder

ShippingandStorage

StoreTemp	4°C
ShipTemp	Ambient

Downloads

MSDS	P3209MSDSPDF
InfoSheet	P3209InfoSheetPDF
Brochures	ResveratrolFlyer
	JAK/STATFlyer

References

YumS,DohHJ,HongS,etal.Piceatannol,ahydroxystilbenenaturalproduct,stabilizesHIF-1αproteinbyinhibitingHIFprolylhydroxylase.EurJPharmacol.2013Jan15;699(1-3):124-31.PMID:23261967.

JayasooriyaRG,LeeYG,KangCH,etal.PiceatannolinhibitsMMP-9-dependentinvasionoftumornecrosisfactor-α-stimulatedDU145cellsbysuppressingtheAkt-mediatednuclearfactor-κBpathway.OncolLett.2013Jan;5(1):341-347.PMID:23255946.

LiZ,YangX,DongS,etal.DNAbreakageinducedbypiceatannolandcopper(II):Mechanismandanticancerproperties.OncolLett.2012May;3(5):1087-1094.PMID:22783397.

KwonJY,SeoSG,HeoYS,etal.Piceatannol,naturalpolyphenolicstilbene,inhibitsadipogenesisviamodulationofmitoticclonalexpansionandinsulinreceptor-dependentinsulinsignalinginearlyphaseofdifferentiation.JBiolChem.2012Mar30;287(14):11566-78.PMID:22298784.

KwonGT,JungJI,SongHR,etal.Piceatannolinhibitsmigrationandinvasionofprostatecancercells:possIBLemediationbydecreasedinterleukin-6signaling.JNutrBiochem.2012Mar;23(3):228-38.PMID:21497499.

LeeYM,LimdoY,ChoHJ,etal.Piceatannol,anaturalstilbenefromgrapes,inducesG1cellcyclearrestinandrogen-insensitiveDU145humanprostatecancercellsviatheinhibitionofCDKactivity.CancerLett.2009Nov28;285(2):166-73.PMID:19487074.

RossiM,CarusoF,OpazoC,etal.Crystalandmolecularstructureofpiceatannol;scavengingfeaturesofresveratrolandpiceatannolonhydroxylandperoxylradicalsanddockingwithtransthyretin.JAgricFoodChem.2008Nov26;56(22):10557-66.PMID:18959413.

KimHJ,LeeKW,KimMS,etal.Piceatannolattenuateshydrogen-peroxide-andperoxynitrite-inducedapoptosisofPC12cellsbyblockingdown-regulationofBcl-XLandactivationofJNK.JNutrBiochem.2008Jul;19(7):459-66.PMID:17869087.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂