Description
Polydatin is a resveratrol-related glucoside originally found in Polygonum cuspidatum. Polydatin exhibits anticancer, anti-inflammatory, antioxidative, and anti-allergic activities. In lung cancer cells, polydatin downregulates expression of cyclin D1 and Bcl-2 and upregulates expression of Bax, inducing cell cycle arrest and apoptosis. In animal models of sepsis, polydatin decreases sepsis-induced mortality and lung injury by suppressing production of COX-2, iNOS, and inflammatory cytokines. Polydatin also decreases the loss of mucosal barrier integrity in the small intestine due to OVA-induced allergy by inhibiting mast cell degranulation.
References
Zhang Y, Zhuang Z, Meng Q, et al. Polydatin inhibits growth of lung cancer cells by inducing apoptosis and causing cell cycle arrest. Oncol Lett. 2014 Jan;7(1):295-301. PMID: 24348867.
Yang B, Li JJ, Cao JJ, et al. Polydatin attenuated food allergy via store-operated calcium channels in mast cell. World J Gastroenterol. 2013 Jul 7;19(25):3980-9. PMID: 23840142.
Li XH, Gong X, Zhang L, et al. Protective effects of polydatin on septic lung injury in mice via upregulation of HO-1. Mediators Inflamm. 2013;2013:354087. PMID: 23431240.
Wu MJ, Gong X, Jiang R, et al. Polydatin protects against lipopolysaccharide-induced fulminant hepatic failure in D-galactosamine-sensitized mice. Int J Immunopathol Pharmacol. 2012 Oct-Dec;25(4):923-34. PMID: 23298483.
