LKT/CHLORPROMAZINE HYDROCHLORIDE/C2947/100 g-免疫在线蚂蚁淘旗下平台

商品详细LKT/CHLORPROMAZINE HYDROCHLORIDE/C2947/100 g

LKT/CHLORPROMAZINE HYDROCHLORIDE/C2947/100 g

商品编号： C2947-100g

品牌： lktlabs

市场价： ¥4760.00

美元价： 2856.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDC2947

CasNo.69-09-0

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Chlorpromazineisaphenothiazinethatexhibitsantipsychotic,antidepressant,anxiolytic,neuroprotective,andanticancerchemotherapeuticactivities.ChlorpromazineinhibitsD1/2/3/4receptors,5-HT1/2receptors,α1/2-adrenergicreceptors,andM1/2muscarinicacetylcholinereceptors(mAChRs).ChlorpromazinestABIlizesmisfoldingmotifsofprions,preventingoligomerization.Additionally,thiscompoundactsasafunctionalinhibitorofacidsphingomyelinase(FIASMA).Invivo,chlorpromazineinducesautophagyandapoptosis,inhibitinggrowthofgliomatumors.

ProductInfo

CasNo.	69-09-0
Purity	≥98%
Formula	C₁₇H₁₉ClN₂S•HCl
FormulaWt.	355.33
ChemicalName	2-Chloro-N,N-dimethyl-10H-phenothiazine-10-propanaminehydrochloride
IUPACName	3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine;hydrochloride
Synonym	Hebanil;Klorpromex;Largactil;Megaphen;Promacid;Chloractil;Sonazine;Marazine;Taroctyl;Torazina
MeltingPoint	179-180°C(dec.)
Solubility	Solubleinmethanol,ethanol(660mg/mL),chloroformorwater(1g/mL).Insolubleinether,orbenzene.
Appearance	WhiteCrystalPowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

MSDS	C2947MSDSPDF
InfoSheet	C2947InfoSheetPDF

References

BaralPK,SwayampakulaM,RoutMK,etal.Structuralbasisofprioninhibitionbyphenothiazinecompounds.Structure.2014Feb4;22(2):291-303.PMID:24373770.

RamosMA.Drugsincontext:ahistoricalperspectiveontheoriesofpsychopharmaceuticalefficacy.JNervMentDis.2013Nov;201(11):926-33.PMID:24177478.

ShinSY,LeeKS,ChoiYK,etal.TheantipsychoticagentchlorpromazineinducesautophagiccelldeathbyinhibitingtheAkt/mTORpathwayinhumanU-87MGgliomacells.Carcinogenesis.2013Sep;34(9):2080-9.PMID:23689352.

BaumeisterAA.Thechlorpromazineenigma.JHistNeurosci.2013;22(1):14-29.PMID:23323529.

KornhuberJ,MuehlbacherM,TrappS,etal.Identificationofnovelfunctionalinhibitorsofacidsphingomyelinase.PLoSOne.2011;6(8):e23852.PMID:21909365.

PeroutkaSJ,SynderSH.Relationshipofneurolepticdrugeffectsatbraindopamine,SEROtonin,alpha-adrenergic,andhistaminereceptorstoclinicalpotency.AmJPsychiatry.1980Dec;137(12):1518-22.PMID:6108081.

MasudaK,KimuraA,HaniehH,etal.ArylhydrocarbonreceptornegativelyregulatesLPS-inducedIL-6productionthroughsuppressionofhistamineproductioninmacrophages.IntImmunol.2011Oct;23(10):637-645.PMID:21930594.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂