CinnarizineisaninhibitorofL-typevoltage-gatedCa2+channelsthatisclinicallyusedtotreatmigraineandvertigo.Cinnarizineexhibitsanticonvulsant/antiepilepticactivityincombinationwithothertherapiesinanimalmodels.ThiscompoundalsoinhibitsD2receptors,suppressingstimulant-inducedlocomotoractivity,andactsasafunctionalinhibitorofacidsphingomyelinase(FIASMA).
| CasNo. | 298-57-7 |
|---|---|
| Purity | ≥98% |
| Formula | C26H28N2 |
| FormulaWt. | 368.51 |
| ChemicalName | 1-benzhydryl-4-cinnamyl-piperazine |
| IUPACName | 1-benzhydryl-4-[(E)-3-phenylprop-2-enyl]piperazine |
| Synonym | Aplactan;Aplexal;Apotomin;Artate;Carecin;Cerebolan;1-trans-Cinnamyl-4-diphenylmethylpiperazine |
| MeltingPoint | 118-122°C |
| Solubility | Practicallyinsolubleinwater.Solubleindichloromethaneorether.Slightlysolubleinmethanol. |
| Appearance | WhiteorAlmost-WhiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | C3251InfoSheetPDF |
|---|
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BrahmaneRI,WanmaliVV,PathakSS,etal.Roleofcinnarizineandnifedipineonanticonvulsanteffectofsodiumvalproateandcarbamazepineinmaximalelectroshockandpentylenetetrazolemodelofseizuresinmice.JPharmacolPharmacother.2010Jul;1(2):78-81.PMID:21350614.
Dall"IgnaOP,TortAB,SouzaDO,etal.Cinnarizinehasanatypicalantipsychoticprofileinanimalmodelsofpsychosis.JPsychopharmacol.2005Jul;19(4):342-6.PMID:15982988.
