Description
Clomipraminehydrochloridedisplaysantidepressantandanxiolyticactivityandmayalsobeusedtotreatnarcolepsyandobsessive-compulsivedisorder(OCD).ThiscompoundinhibitsSEROtonintransporters(SERT),norepinephrinetransporters(NET),histaminereceptors,muscarinicacetylcholinereceptors(mAChRs),α1/2-adrenergicreceptors,and5-HT2/3/6/7receptors.ClomipraminehydrochloridealsoinhibitsL-typeCa2+channelsandexhibitsantinociceptiveactivityinanimalmodelsofthermalandmechanicalpainstimulation.Additionally,thiscompoundmayprolongthecardiacQTintervalthoughitsABIlitytodecreasecurrentamplitudefromhERGK+channels.Clomipraminealsoactsasafunctionalinhibitorofacidsphingomyelinase(FIASMA).
References
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