Description
Cortistatin-14 is an endogenous neuropeptide related to somatostatin that binds and activates somatostatin and ghrelin receptors, inhibiting secretion of growth hormone and insulin. Cortistatin-14 exhibits anticonvulsant/antiepileptic, anti-inflammatory, and antinociceptive activities. In animal models, cortistatin-14 decreases seizure duration. In macrophages, this peptide inhibits production of IL-1β. Similarly, cortistatin-14 decreases capsaicin-induced release of CGRP in rat trachea and suppresses carrageenan-induced edema in other animal models.
References
Aourz N, Portelli J, Coppens J, et al. Cortistatin-14 Mediates its Anticonvulsant Effects Via sst2 and sst3 but Not Ghrelin Receptors. CNS Neurosci Ther. 2014 Mar 31. [Epub ahead of print]. PMID: 24685142.
Markovics A, Szoke É, Sándor K, et al. Comparison of the anti-inflammatory and anti-nociceptive effects of cortistatin-14 and somatostatin-14 in distinct in vitro and in vivo model systems. J Mol Neurosci. 2012 Jan;46(1):40-50. PMID: 21695504.
Broglio F, Arvat E, Benso A, et al. Endocrine activities of cortistatin-14 and its interaction with GHRH and ghrelin in humans. J Clin Endocrinol Metab. 2002 Aug;87(8):3783-90. PMID: 12161511.
